Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection
OBJECTIVE: To compare the result of intracytoplasmic sperm injection cycles using gonadotrophins with those of using gonadotrophins combined with letrozole in infertile woman with biopsy-proven endometriosis. STUDY DESIGN: This prospective randomized study was performed at the department of Obstetr...
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| Format: | Article |
| Language: | English |
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Medical Network
2014-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/128 |
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| author | Burak Tanır Mehmet Serdar Kütük Mehmet Dolanbay Mahmut Tuncay Özgün Semih Uludağ Ercan Aygen Yılmaz Şahin |
| author_facet | Burak Tanır Mehmet Serdar Kütük Mehmet Dolanbay Mahmut Tuncay Özgün Semih Uludağ Ercan Aygen Yılmaz Şahin |
| author_sort | Burak Tanır |
| collection | DOAJ |
| description |
OBJECTIVE: To compare the result of intracytoplasmic sperm injection cycles using gonadotrophins with those of using gonadotrophins combined with letrozole in infertile woman with biopsy-proven endometriosis.
STUDY DESIGN: This prospective randomized study was performed at the department of Obstetrics and Gynecology Reproductive Center, in Erciyes University. Thirty- three women undergoing intracytoplasmic sperm injection (ICSI) with gonadotropin or combination of gonadotropin with letrozole were accepted.
The patients were grouped as: gonadotropin group (Group 1), and gonadotropin plus letrozole (Group 2). Total and clinical pregnancy ratios, length of cycles, and doses of gonadotropin used were compared.
RESULTS: Total doses of gonadotrophins used in group 1, and group 2 were 2700 (1800- 3600) IU and 2100 (1575- 3475) IU, respectively. Total dose of gonadotropin used in group 2 was found to be lower than that of group one and this difference was statistically significant (p= 0.002). Stimulation times in group 1 and 2 were 10 (9- 12) day, and (7- 12) day, respectively, and the difference was statistically significant (p=0.048). Number of the retrieved oocytes were higher in group 2 than Group 1(p=0.027). There was no statistically significant difference between groups with regard to numbers of embryos, total and clinical pregnancy ratio.
CONCLUSIONS: Letrozole has no effect on the results of ICSI success in infertile women with biopsy proven- endometriosis. However, it reduces the gonadotropin dose used, stimulation time and, cost of the therapy.
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| format | Article |
| id | doaj-art-848b42a08759441ba5fa39ae3e3be685 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2014-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-848b42a08759441ba5fa39ae3e3be6852025-02-11T21:23:11ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182014-04-0120170Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm InjectionBurak Tanır0Mehmet Serdar Kütük1Mehmet Dolanbay2Mahmut Tuncay Özgün3Semih Uludağ4Ercan Aygen5Yılmaz Şahin6Erciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, KayseriErciyes University Faculty of Medicine Department of Obstetrics and Gynecology, Kayseri OBJECTIVE: To compare the result of intracytoplasmic sperm injection cycles using gonadotrophins with those of using gonadotrophins combined with letrozole in infertile woman with biopsy-proven endometriosis. STUDY DESIGN: This prospective randomized study was performed at the department of Obstetrics and Gynecology Reproductive Center, in Erciyes University. Thirty- three women undergoing intracytoplasmic sperm injection (ICSI) with gonadotropin or combination of gonadotropin with letrozole were accepted. The patients were grouped as: gonadotropin group (Group 1), and gonadotropin plus letrozole (Group 2). Total and clinical pregnancy ratios, length of cycles, and doses of gonadotropin used were compared. RESULTS: Total doses of gonadotrophins used in group 1, and group 2 were 2700 (1800- 3600) IU and 2100 (1575- 3475) IU, respectively. Total dose of gonadotropin used in group 2 was found to be lower than that of group one and this difference was statistically significant (p= 0.002). Stimulation times in group 1 and 2 were 10 (9- 12) day, and (7- 12) day, respectively, and the difference was statistically significant (p=0.048). Number of the retrieved oocytes were higher in group 2 than Group 1(p=0.027). There was no statistically significant difference between groups with regard to numbers of embryos, total and clinical pregnancy ratio. CONCLUSIONS: Letrozole has no effect on the results of ICSI success in infertile women with biopsy proven- endometriosis. However, it reduces the gonadotropin dose used, stimulation time and, cost of the therapy. https://gorm.com.tr/index.php/GORM/article/view/128InfertilityEndometriosisICSILetrozoleGonadotropin |
| spellingShingle | Burak Tanır Mehmet Serdar Kütük Mehmet Dolanbay Mahmut Tuncay Özgün Semih Uludağ Ercan Aygen Yılmaz Şahin Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection Gynecology Obstetrics & Reproductive Medicine Infertility Endometriosis ICSI Letrozole Gonadotropin |
| title | Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection |
| title_full | Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection |
| title_fullStr | Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection |
| title_full_unstemmed | Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection |
| title_short | Comparison of Gonadotropin with Gonadotropin and Letrozole Combination in Infertile Women with Biopsy - Proven Endometriosis Undergoing Intracytoplasmic Sperm Injection |
| title_sort | comparison of gonadotropin with gonadotropin and letrozole combination in infertile women with biopsy proven endometriosis undergoing intracytoplasmic sperm injection |
| topic | Infertility Endometriosis ICSI Letrozole Gonadotropin |
| url | https://gorm.com.tr/index.php/GORM/article/view/128 |
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