Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population
Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2016/7030272 |
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| author | Petar Avramovski Maja Avramovska Aleksandar Sikole |
| author_facet | Petar Avramovski Maja Avramovska Aleksandar Sikole |
| author_sort | Petar Avramovski |
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| description | Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852±0.1432 g/cm2, 0.934±0.1546 g/cm2, and 9.209±1.9815 m/s. In multiple regression analysis we found BMD FN (βst =-6.0094, p<0.0001), hypertension (βst = 1.7340, p<0.0091), and diabetes (βst=0.4595, p<0.0046). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN (b=-2.4129, p=0.015) and PWV (b=0.2606, p=0.0318). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm2, and BMD LS = 0.992 g/cm2. The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP. |
| format | Article |
| id | doaj-art-8485c8b26d7640c7ad586012a8a3f2c2 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-8485c8b26d7640c7ad586012a8a3f2c22025-08-20T03:37:11ZengWileyJournal of Osteoporosis2090-80592042-00642016-01-01201610.1155/2016/70302727030272Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General PopulationPetar Avramovski0Maja Avramovska1Aleksandar Sikole2JZU Clinical Hospital “Dr. Trifun Panovski”, Department of Internal Medicine, 7000 Bitola, MacedoniaUniversity Clinic of Obstetrics and Gynecology, Medical Faculty, “Ss. Cyril and Methodius University” in Skopje, 1000 Skopje, MacedoniaUniversity Clinic of Nephrology, Medical Faculty, “Ss. Cyril and Methodius University” in Skopje, 1000 Skopje, MacedoniaOsteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852±0.1432 g/cm2, 0.934±0.1546 g/cm2, and 9.209±1.9815 m/s. In multiple regression analysis we found BMD FN (βst =-6.0094, p<0.0001), hypertension (βst = 1.7340, p<0.0091), and diabetes (βst=0.4595, p<0.0046). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN (b=-2.4129, p=0.015) and PWV (b=0.2606, p=0.0318). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm2, and BMD LS = 0.992 g/cm2. The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP.http://dx.doi.org/10.1155/2016/7030272 |
| spellingShingle | Petar Avramovski Maja Avramovska Aleksandar Sikole Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population Journal of Osteoporosis |
| title | Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population |
| title_full | Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population |
| title_fullStr | Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population |
| title_full_unstemmed | Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population |
| title_short | Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population |
| title_sort | bone strength and arterial stiffness impact on cardiovascular mortality in a general population |
| url | http://dx.doi.org/10.1155/2016/7030272 |
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