Sleep disorders and Alzheimer’s disease: relationship and mechanisms involving neuroinflammation, orexin and Aβ

Sleep disorders and Alzheimer’s disease: relationship and mechanisms involving neuroinflammation, orexin and Aβ

Abstract Aims Sleep disorders are common in Alzheimer’s disease (AD), but the underlying mechanisms are unknown. This study aimed to specifically investigate the relationship between a specific sleep disorder of short sleep duration (SSD) and AD, and related mechanisms involving neuroinflammation, o...

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Main Authors: Wenjing Zhang, Tenghong Lian, Mingyue He, Peng Guo, Huiying Guan, Jinghui Li, Jing Qi, Dongmei Luo, Jing Li, Yanan Zhang, Yue Huang, Gaifen Liu, Weijia Zhang, Zijing Zheng, Hao Yue, Zhan Liu, Fan Zhang, Ruidan Wang, Yao Meng, Wei Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Fluids and Barriers of the CNS
Subjects:
Alzheimer’s disease
Short sleep duration
Neuroinflammation
Orexin
β amyloid
Cerebrospinal fluid
Online Access:https://doi.org/10.1186/s12987-025-00638-9
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