Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes
Polymorphonuclear leukocytes (PMNs) are the major leukocytes in the circulation and play an important role in host defense. Intact PMN functions include adhesion, migration, phagocytosis, and reactive oxygen species (ROS) release. It has been known for a long time that adenosine can function as a mo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/387923 |
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| author | Pei-Chen Hou Hong-Ren Yu Ho-Chang Kuo Lin Wang Li-Yan Lin Jiunn-Ming Sheen Te-Yao Hsu Chia-Yu Ou Yi-Jyun Jheng Kuender D. Yang Wen-Hsin Cheng |
| author_facet | Pei-Chen Hou Hong-Ren Yu Ho-Chang Kuo Lin Wang Li-Yan Lin Jiunn-Ming Sheen Te-Yao Hsu Chia-Yu Ou Yi-Jyun Jheng Kuender D. Yang Wen-Hsin Cheng |
| author_sort | Pei-Chen Hou |
| collection | DOAJ |
| description | Polymorphonuclear leukocytes (PMNs) are the major leukocytes in the circulation and play an important role in host defense. Intact PMN functions include adhesion, migration, phagocytosis, and reactive oxygen species (ROS) release. It has been known for a long time that adenosine can function as a modulator of adult PMN functions. Neonatal plasma has a higher adenosine level than that of adults; however, little is known about the modulating effects of adenosine on neonatal PMNs. The aim of this study was to investigate the effects of adenosine on neonatal PMN functions. We found that neonatal PMNs had impaired adhesion, chemotaxis, and ROS production abilities, but not phagocytosis compared to adult PMNs. As with adult PMNs, adenosine could suppress the CD11b expressions of neonatal PMNs, but had no significant suppressive effect on phagocytosis. In contrast to adult PMNs, adenosine did not significantly suppress chemotaxis and ROS production of neonatal PMNs. This may be due to impaired phagocyte reactions and a poor neonatal PMN response to adenosine. Adenosine may not be a good strategy for the treatment of neonatal sepsis because of impaired phagocyte reactions and poor response. |
| format | Article |
| id | doaj-art-8478c98573824355afce57c562a87462 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8478c98573824355afce57c562a874622025-02-03T01:32:26ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/387923387923Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear LeukocytesPei-Chen Hou0Hong-Ren Yu1Ho-Chang Kuo2Lin Wang3Li-Yan Lin4Jiunn-Ming Sheen5Te-Yao Hsu6Chia-Yu Ou7Yi-Jyun Jheng8Kuender D. Yang9Wen-Hsin Cheng10Department of Nursing, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Niao-Sung district, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Obstetrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Obstetrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung 833, TaiwanDepartment of Pediatrics, Show Chwan Health Care System, Changhua 505, TaiwanDepartment of Nursing, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Niao-Sung district, Kaohsiung 833, TaiwanPolymorphonuclear leukocytes (PMNs) are the major leukocytes in the circulation and play an important role in host defense. Intact PMN functions include adhesion, migration, phagocytosis, and reactive oxygen species (ROS) release. It has been known for a long time that adenosine can function as a modulator of adult PMN functions. Neonatal plasma has a higher adenosine level than that of adults; however, little is known about the modulating effects of adenosine on neonatal PMNs. The aim of this study was to investigate the effects of adenosine on neonatal PMN functions. We found that neonatal PMNs had impaired adhesion, chemotaxis, and ROS production abilities, but not phagocytosis compared to adult PMNs. As with adult PMNs, adenosine could suppress the CD11b expressions of neonatal PMNs, but had no significant suppressive effect on phagocytosis. In contrast to adult PMNs, adenosine did not significantly suppress chemotaxis and ROS production of neonatal PMNs. This may be due to impaired phagocyte reactions and a poor neonatal PMN response to adenosine. Adenosine may not be a good strategy for the treatment of neonatal sepsis because of impaired phagocyte reactions and poor response.http://dx.doi.org/10.1100/2012/387923 |
| spellingShingle | Pei-Chen Hou Hong-Ren Yu Ho-Chang Kuo Lin Wang Li-Yan Lin Jiunn-Ming Sheen Te-Yao Hsu Chia-Yu Ou Yi-Jyun Jheng Kuender D. Yang Wen-Hsin Cheng Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes The Scientific World Journal |
| title | Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes |
| title_full | Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes |
| title_fullStr | Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes |
| title_full_unstemmed | Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes |
| title_short | Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes |
| title_sort | different modulating effects of adenosine on neonatal and adult polymorphonuclear leukocytes |
| url | http://dx.doi.org/10.1100/2012/387923 |
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