Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy

Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy

Abstract Duchenne muscular dystrophy (DMD) is a debilitating fatal X‐linked muscle disorder. Recent findings indicate that IGFs play a central role in skeletal muscle regeneration and development. Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth, survival, migration a...

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Main Authors: Pamela Bella, Andrea Farini, Stefania Banfi, Daniele Parolini, Noemi Tonna, Mirella Meregalli, Marzia Belicchi, Silvia Erratico, Pasqualina D'Ursi, Fabio Bianco, Mariella Legato, Chiara Ruocco, Clementina Sitzia, Simone Sangiorgi, Chiara Villa, Giuseppe D'Antona, Luciano Milanesi, Enzo Nisoli, PierLuigi Mauri, Yvan Torrente
Format: Article
Language:English
Published: Springer Nature 2019-12-01
Series:EMBO Molecular Medicine
Subjects:
DMD
IGF2
IGF2R
muscle regeneration
muscular dystrophy
Online Access:https://doi.org/10.15252/emmm.201911019
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