Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort
<b>Background:</b> The aim of this study was to investigate the accuracy in fibrosis staging of a novel shear wave elastography (SWE) device (S-Shearwave Imaging by Samsung) and a previously validated 2D-SWE by Supersonic Imagine (SSI) in patients with biopsy proven metabolic dysfunction...
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MDPI AG
2025-01-01
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| author | Antonio Liguori Giorgio Esposto Maria Elena Ainora Irene Mignini Raffaele Borriello Linda Galasso Mattia Paratore Maria Cristina Giustiniani Laura Riccardi Matteo Garcovich Antonio Gasbarrini Luca Miele Maria Assunta Zocco |
| author_facet | Antonio Liguori Giorgio Esposto Maria Elena Ainora Irene Mignini Raffaele Borriello Linda Galasso Mattia Paratore Maria Cristina Giustiniani Laura Riccardi Matteo Garcovich Antonio Gasbarrini Luca Miele Maria Assunta Zocco |
| author_sort | Antonio Liguori |
| collection | DOAJ |
| description | <b>Background:</b> The aim of this study was to investigate the accuracy in fibrosis staging of a novel shear wave elastography (SWE) device (S-Shearwave Imaging by Samsung) and a previously validated 2D-SWE by Supersonic Imagine (SSI) in patients with biopsy proven metabolic dysfunction-associated steatotic liver disease (MASLD). <b>Methods:</b> This prospective study included 75 consecutive patients with MASLD who underwent liver biopsy for suspected MASH. All patients underwent S-Shearwave Imaging by Samsung and 2D-SWE with SSI on the same day of liver biopsy. Fibrosis was histologically assessed using the METAVIR classification system. Agreement between the equipment was assessed with the Pearson coefficient. A receiver operator characteristic curve (ROC) analysis with the Youden index was used to establish thresholds for fibrosis staging. <b>Results:</b> A good correlation was found between S-Shearwave Imaging by Samsung and 2D-SWE with SSI (Pearson’s R = 0.68; <i>p</i> < 0.01). At multivariate regression analysis, S-Shearwave Imaging was associated with advanced fibrosis (≥F3) independently from age, diabetes and platelets (OR 2.94, CI 1.69–5.11, <i>p</i> < 0.01). The fibrosis diagnostic accuracy of both S-Shearwave Imaging and 2D-SWE was good to optimal with AUROCs of 0.81 and 0.70 for significant fibrosis (≥F2), 0.94 and 0.91 for severe fibrosis (≥F3), respectively. The accuracy of S-Shearwave is not significantly different from Fibroscan and Agile3+ (DeLong test <i>p</i> value 0.16 and 0.15, respectively) while is slightly better than 2D-SWE, FIB4 and NFS (DeLong test <i>p</i> value < 0.05). For S-Shearwave Imaging by Samsung, the best cut-off values for diagnosing fibrosis ≥F2, ≥F3 were, respectively, 7.9 kPa (Sens 74.4%, Spec 87.5%) and 8.1 kPa (Sens 95.6%, Spec 78.8%). For 2D-SWE by SSI, the best cut-off values for diagnosing fibrosis ≥F2, ≥F3 were, respectively, 7.2 kPa (Sens 55.8%, Spec 84.4%) and 7.6 kPa (Sens 82.6%, Spec 84.6%). <b>Conclusion:</b> S-Shearwave Imaging is a useful and reliable non-invasive technique for staging liver fibrosis in patients with MASLD. Its diagnostic accuracy is non-inferior to other shear wave elastography techniques (TE and 2D-SWE by SSI). |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-8475f0a2314a49699e0f166fd60054482025-01-24T13:24:08ZengMDPI AGBiomedicines2227-90592025-01-0113113810.3390/biomedicines13010138Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD CohortAntonio Liguori0Giorgio Esposto1Maria Elena Ainora2Irene Mignini3Raffaele Borriello4Linda Galasso5Mattia Paratore6Maria Cristina Giustiniani7Laura Riccardi8Matteo Garcovich9Antonio Gasbarrini10Luca Miele11Maria Assunta Zocco12Centro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyDipartimento di Scienze Della Salute Della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyCentro Malattie Apparato Digerente—CEMAD, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy<b>Background:</b> The aim of this study was to investigate the accuracy in fibrosis staging of a novel shear wave elastography (SWE) device (S-Shearwave Imaging by Samsung) and a previously validated 2D-SWE by Supersonic Imagine (SSI) in patients with biopsy proven metabolic dysfunction-associated steatotic liver disease (MASLD). <b>Methods:</b> This prospective study included 75 consecutive patients with MASLD who underwent liver biopsy for suspected MASH. All patients underwent S-Shearwave Imaging by Samsung and 2D-SWE with SSI on the same day of liver biopsy. Fibrosis was histologically assessed using the METAVIR classification system. Agreement between the equipment was assessed with the Pearson coefficient. A receiver operator characteristic curve (ROC) analysis with the Youden index was used to establish thresholds for fibrosis staging. <b>Results:</b> A good correlation was found between S-Shearwave Imaging by Samsung and 2D-SWE with SSI (Pearson’s R = 0.68; <i>p</i> < 0.01). At multivariate regression analysis, S-Shearwave Imaging was associated with advanced fibrosis (≥F3) independently from age, diabetes and platelets (OR 2.94, CI 1.69–5.11, <i>p</i> < 0.01). The fibrosis diagnostic accuracy of both S-Shearwave Imaging and 2D-SWE was good to optimal with AUROCs of 0.81 and 0.70 for significant fibrosis (≥F2), 0.94 and 0.91 for severe fibrosis (≥F3), respectively. The accuracy of S-Shearwave is not significantly different from Fibroscan and Agile3+ (DeLong test <i>p</i> value 0.16 and 0.15, respectively) while is slightly better than 2D-SWE, FIB4 and NFS (DeLong test <i>p</i> value < 0.05). For S-Shearwave Imaging by Samsung, the best cut-off values for diagnosing fibrosis ≥F2, ≥F3 were, respectively, 7.9 kPa (Sens 74.4%, Spec 87.5%) and 8.1 kPa (Sens 95.6%, Spec 78.8%). For 2D-SWE by SSI, the best cut-off values for diagnosing fibrosis ≥F2, ≥F3 were, respectively, 7.2 kPa (Sens 55.8%, Spec 84.4%) and 7.6 kPa (Sens 82.6%, Spec 84.6%). <b>Conclusion:</b> S-Shearwave Imaging is a useful and reliable non-invasive technique for staging liver fibrosis in patients with MASLD. Its diagnostic accuracy is non-inferior to other shear wave elastography techniques (TE and 2D-SWE by SSI).https://www.mdpi.com/2227-9059/13/1/138SWEShearwave elastographyliver fibrosisMASLD |
| spellingShingle | Antonio Liguori Giorgio Esposto Maria Elena Ainora Irene Mignini Raffaele Borriello Linda Galasso Mattia Paratore Maria Cristina Giustiniani Laura Riccardi Matteo Garcovich Antonio Gasbarrini Luca Miele Maria Assunta Zocco Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort Biomedicines SWE Shearwave elastography liver fibrosis MASLD |
| title | Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort |
| title_full | Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort |
| title_fullStr | Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort |
| title_full_unstemmed | Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort |
| title_short | Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort |
| title_sort | liver elastography for liver fibrosis stratification a comparison of three techniques in a biopsy controlled masld cohort |
| topic | SWE Shearwave elastography liver fibrosis MASLD |
| url | https://www.mdpi.com/2227-9059/13/1/138 |
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