EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES
The study is to investigate the potential protective effect of sevoflurane on adriamycin induced myocyte injury. We prepared primary myocyte culture from neonatal rats and subjected the cells to adriamycin treatment. We found that adriamycin treatment induced cell apoptosis, decreased cell vitality,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-01-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/589 |
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| _version_ | 1849250780872179712 |
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| author | Li-hua Fan Xin Han Qing-quan Lian Jun Li Hou-xing Lei NIing Zhang Xiang-dong Xu Xiang-hong Lu |
| author_facet | Li-hua Fan Xin Han Qing-quan Lian Jun Li Hou-xing Lei NIing Zhang Xiang-dong Xu Xiang-hong Lu |
| author_sort | Li-hua Fan |
| collection | DOAJ |
| description | The study is to investigate the potential protective effect of sevoflurane on adriamycin induced myocyte injury. We prepared primary myocyte culture from neonatal rats and subjected the cells to adriamycin treatment. We found that adriamycin treatment induced cell apoptosis, decreased cell vitality, which could be reversed with sevoflurane exposure after the drug treatment, potentially through the regulation of Bcl-2 anti-apoptotic pathway. The study suggested the potential roles of sevoflurane in clinical management of patients after adriamycin chemotherapy. |
| format | Article |
| id | doaj-art-846f869441e64e5cab555730bc7008df |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-01-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-846f869441e64e5cab555730bc7008df2025-08-20T03:57:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-01-0101-ENG323410.15829/1560-4071-2014-1-ENG-32-34536EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTESLi-hua Fan0Xin Han1Qing-quan Lian2Jun Li3Hou-xing Lei4NIing Zhang5Xiang-dong Xu6Xiang-hong Lu7Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaDepartment of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, ChinaThe study is to investigate the potential protective effect of sevoflurane on adriamycin induced myocyte injury. We prepared primary myocyte culture from neonatal rats and subjected the cells to adriamycin treatment. We found that adriamycin treatment induced cell apoptosis, decreased cell vitality, which could be reversed with sevoflurane exposure after the drug treatment, potentially through the regulation of Bcl-2 anti-apoptotic pathway. The study suggested the potential roles of sevoflurane in clinical management of patients after adriamycin chemotherapy.https://russjcardiol.elpub.ru/jour/article/view/589anestheticssevofluranemyocytechemotherapyadriamycin |
| spellingShingle | Li-hua Fan Xin Han Qing-quan Lian Jun Li Hou-xing Lei NIing Zhang Xiang-dong Xu Xiang-hong Lu EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES Российский кардиологический журнал anesthetics sevoflurane myocyte chemotherapy adriamycin |
| title | EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES |
| title_full | EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES |
| title_fullStr | EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES |
| title_full_unstemmed | EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES |
| title_short | EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES |
| title_sort | effect of sevoflurane exposure on adriamycin induced injuries to myocytes |
| topic | anesthetics sevoflurane myocyte chemotherapy adriamycin |
| url | https://russjcardiol.elpub.ru/jour/article/view/589 |
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