An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan
Abstract Highly variable response shown by individuals against mosquito-borne infections suggests that host genetic factors play an important role in determining mosquito-borne disease onset. Therefore, it is necessary to determine the genetic risk of these diseases in specific populations. The curr...
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2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88095-0 |
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| author | Rabea Basri Muslim Bin Aqeel Faryal Mehwish Awan Sadiq Noor Khan Ayesha Obaid Rubina Parveen Muhammad Mohsin Wajeeha Akhtar Abdal Hussain Shah Tahira Sher Afghan Amir Alam Saira Khan Anam Naz |
| author_facet | Rabea Basri Muslim Bin Aqeel Faryal Mehwish Awan Sadiq Noor Khan Ayesha Obaid Rubina Parveen Muhammad Mohsin Wajeeha Akhtar Abdal Hussain Shah Tahira Sher Afghan Amir Alam Saira Khan Anam Naz |
| author_sort | Rabea Basri |
| collection | DOAJ |
| description | Abstract Highly variable response shown by individuals against mosquito-borne infections suggests that host genetic factors play an important role in determining mosquito-borne disease onset. Therefore, it is necessary to determine the genetic risk of these diseases in specific populations. The current study aimed to determine the percentage of individuals in the general population carrying mosquito-borne disease susceptibility and protection-related variants. This study initially aggregated mosquito-borne disease susceptibility and protection-related variants from all publically available data and literature. Afterward, the allele frequency was calculated 1009 genetic variants of 366 genes associated with susceptibility and protection to estimate the global prevalence in multiple ethnicities (Middle Eastern, Ashkenazi Jewish, European (Non-Finnish), Latino/Admixed American, South Asian, East Asian, European (Finnish), North Asian, Southeast Asian, African American, and Swedish population). Furthermore, the cumulative allele frequency of all susceptibility and protection-related variants was calculated in diverse ethnic groups and the relationship with mosquito-borne disease-associated morbidity and mortality was examined to determine whether results are consistent with founder effect in these populations. Two prioritized genetic variants of IL-10 (rs1800871) and FcγRIIA (rs1801274) were examined in the Tehsil Haripur population to assess the genetic risks linked to susceptibility and protection against mosquito-borne diseases. The findings of this study revealed overlapping genes most implicated in mosquito-borne disease linked with susceptibility and protection across different ethnic ancestries. In the available sample size, the percentage of TC and TT genotypes in IL-10 genetic variant (rs1800871) was 12% and 88%, respectively and GA and GG genotypes in FcγRIIA (rs1801274) genetic variant were 6% and 94% respectively. Based on statistical analysis, the percentage allele frequency of IL-10 (rs1800871) variant was 0.2112% and the FcγRIIA (rs1801274) variant is 0.1128% in the current study. Additionally, this study reflects that screening of genetic variants associated with susceptibility and protection in a population gives better insights into organizing public health awareness campaigns to control diseases. |
| format | Article |
| id | doaj-art-846520c537bc48b69e5127a44638e238 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Scientific Reports |
| spelling | doaj-art-846520c537bc48b69e5127a44638e2382025-02-02T12:24:39ZengNature PortfolioScientific Reports2045-23222025-01-0115112210.1038/s41598-025-88095-0An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, PakistanRabea Basri0Muslim Bin Aqeel1Faryal Mehwish Awan2Sadiq Noor Khan3Ayesha Obaid4Rubina Parveen5Muhammad Mohsin6Wajeeha Akhtar7Abdal Hussain Shah8Tahira Sher Afghan9Amir Alam10Saira Khan11Anam Naz12Department of Medical Lab Technology, The University of Haripur (UOH)Department of Microbiology, Faculty of Science and Technology, University of Central PunjabDepartment of Medical Lab Technology, The University of Haripur (UOH)Department of Medical Lab Technology, The University of Haripur (UOH)Department of Medical Lab Technology, The University of Haripur (UOH)Department of Medical Lab Technology, The University of Haripur (UOH)Medical Research Center, The Second Affiliated Hospital of Zhengzhou UniversityDepartment of Medical Lab Technology, The University of Haripur (UOH)Department of Medical Lab Technology, The University of Haripur (UOH)Department of Medical Lab Technology, The University of Haripur (UOH)The Second Affiliated Hospital of Zhengzhou UniversityDepartment of Medical Lab Technology, The University of Haripur (UOH)Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore (UOL)Abstract Highly variable response shown by individuals against mosquito-borne infections suggests that host genetic factors play an important role in determining mosquito-borne disease onset. Therefore, it is necessary to determine the genetic risk of these diseases in specific populations. The current study aimed to determine the percentage of individuals in the general population carrying mosquito-borne disease susceptibility and protection-related variants. This study initially aggregated mosquito-borne disease susceptibility and protection-related variants from all publically available data and literature. Afterward, the allele frequency was calculated 1009 genetic variants of 366 genes associated with susceptibility and protection to estimate the global prevalence in multiple ethnicities (Middle Eastern, Ashkenazi Jewish, European (Non-Finnish), Latino/Admixed American, South Asian, East Asian, European (Finnish), North Asian, Southeast Asian, African American, and Swedish population). Furthermore, the cumulative allele frequency of all susceptibility and protection-related variants was calculated in diverse ethnic groups and the relationship with mosquito-borne disease-associated morbidity and mortality was examined to determine whether results are consistent with founder effect in these populations. Two prioritized genetic variants of IL-10 (rs1800871) and FcγRIIA (rs1801274) were examined in the Tehsil Haripur population to assess the genetic risks linked to susceptibility and protection against mosquito-borne diseases. The findings of this study revealed overlapping genes most implicated in mosquito-borne disease linked with susceptibility and protection across different ethnic ancestries. In the available sample size, the percentage of TC and TT genotypes in IL-10 genetic variant (rs1800871) was 12% and 88%, respectively and GA and GG genotypes in FcγRIIA (rs1801274) genetic variant were 6% and 94% respectively. Based on statistical analysis, the percentage allele frequency of IL-10 (rs1800871) variant was 0.2112% and the FcγRIIA (rs1801274) variant is 0.1128% in the current study. Additionally, this study reflects that screening of genetic variants associated with susceptibility and protection in a population gives better insights into organizing public health awareness campaigns to control diseases.https://doi.org/10.1038/s41598-025-88095-0Allele frequency in PakistanGenetic factorsMosquito-Borne diseasesARMS-PCR |
| spellingShingle | Rabea Basri Muslim Bin Aqeel Faryal Mehwish Awan Sadiq Noor Khan Ayesha Obaid Rubina Parveen Muhammad Mohsin Wajeeha Akhtar Abdal Hussain Shah Tahira Sher Afghan Amir Alam Saira Khan Anam Naz An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan Scientific Reports Allele frequency in Pakistan Genetic factors Mosquito-Borne diseases ARMS-PCR |
| title | An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan |
| title_full | An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan |
| title_fullStr | An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan |
| title_full_unstemmed | An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan |
| title_short | An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan |
| title_sort | integrated approach to predict genetic risk for mosquito borne diseases in the local population of tehsil haripur khyber pakhtunkhwa pakistan |
| topic | Allele frequency in Pakistan Genetic factors Mosquito-Borne diseases ARMS-PCR |
| url | https://doi.org/10.1038/s41598-025-88095-0 |
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