CARG-2020 targets IL-12, IL-17, and PD-L1 pathways to effectively treat melanoma and breast cancer

CARG-2020 targets IL-12, IL-17, and PD-L1 pathways to effectively treat melanoma and breast cancer

Abstract Cancer immunotherapy has recently achieved a breakthrough status, however, it is not effective in all cancer types. Genetically engineered oncolytic viruses (OVs) with immunomodulators are promising new therapeutic modalities for cancer. CARG-2020 is an engineered trivalent oncolytic viral...

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Bibliographic Details
Main Authors: Elham Ahmadi, Conner Chiari, Bhaskara Reddy Madina, Timur Olegovich Yarovinsky, Marie Marthe Krady, Ju Chen, Bijan Almassian, Valerian Nakaar, Kepeng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Oncolytic virus
Cancer immunotherapy
Interleukin-12
Interleukin-17
PD-L1
Online Access:https://doi.org/10.1038/s41598-025-14750-1
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