The role of PD-1/PD-L1 in overshooting osteoclastogenesis in periprosthetic joint infections

The role of PD-1/PD-L1 in overshooting osteoclastogenesis in periprosthetic joint infections

Abstract Periprosthetic joint infection (PJI) is a critical complication following arthroplasty, leading to increased prosthesis failure rates post-treatment. This study explores the role of PD-1/PD-L1 signaling in osteoclastogenesis associated with PJI. Peripheral blood, bone, and bone marrow of 65...

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Main Authors: Yi Ren, Denise Jahn, Stefanie Donner, Clemens Gwinner, Weijie Du, Dimitrios L. Wagner, Serafeim Tsitsilonis, Carsten Perka, Georg Duda, Arne Kienzle
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08143-3
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