Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study
Abstract An imbalance in the serum sodium to chloride ratio (Na/Cl) was linked to higher mortality among heart failure patients. Nonetheless, the prognostic significance of Na/Cl in individuals undergoing peritoneal dialysis (PD) remains unexplored. This study seeks to explore the association betwee...
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2025-01-01
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| Online Access: | https://doi.org/10.1002/mco2.70041 |
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| author | Jiayin You Sijie Gu Ning Su Xiaoran Feng Fenfen Peng Qingdong Xu Xiaojiang Zhan Yueqiang Wen Xiaoyang Wang Na Tian Xianfeng Wu Niansong Wang |
| author_facet | Jiayin You Sijie Gu Ning Su Xiaoran Feng Fenfen Peng Qingdong Xu Xiaojiang Zhan Yueqiang Wen Xiaoyang Wang Na Tian Xianfeng Wu Niansong Wang |
| author_sort | Jiayin You |
| collection | DOAJ |
| description | Abstract An imbalance in the serum sodium to chloride ratio (Na/Cl) was linked to higher mortality among heart failure patients. Nonetheless, the prognostic significance of Na/Cl in individuals undergoing peritoneal dialysis (PD) remains unexplored. This study seeks to explore the association between initial Na/Cl levels and mortality in PD patients. The study, conducted across multiple centers, included 3341 patients undergoing PD from January 1, 2005, to December 31, 2021. Patients were stratified into quartiles according to baseline Na/Cl and followed up for a median of 5.77 years. To explore the association between Na/Cl levels and mortality, we employed Cox proportional hazards models, competing risks models, and restricted cubic spline analysis. Of 3341 patients, 722 patients died, including 259 cardiovascular deaths. Following adjustments for comorbidities and multiple covariates, individuals in the highest Na/Cl quartile (>1.42) exhibited lower all‐cause mortality (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.47–0.86) and cardiovascular mortality (HR 0.38, 95% CI 0.22–0.67) compared with those in the lowest quartile (<1.33). A similar pattern was also found when Na/Cl was dealt with continuous variables. Initial levels of Na/Cl at the start of PD were negatively correlated with all‐cause mortality and cardiovascular mortality in PD patients. |
| format | Article |
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| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-84587f83e1634c0b91b17ffff08860f12025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70041Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective studyJiayin You0Sijie Gu1Ning Su2Xiaoran Feng3Fenfen Peng4Qingdong Xu5Xiaojiang Zhan6Yueqiang Wen7Xiaoyang Wang8Na Tian9Xianfeng Wu10Niansong Wang11Department of Nephrology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Nephrology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Nephrology The Sixth Affiliated Hospital of Sun Yat‐Sen University Guangzhou ChinaDepartment of Nephrology Jiujiang NO.1 People's Hospital Jiujiang ChinaDepartment of Nephrology Zhujiang Hospital Southern Medical University Zhujiang ChinaDepartment of Nephrology Jiangmen Central Hospital Jiangmen ChinaDepartment of Nephrology The First Affiliated Hospital of Nanchang University Nanchang ChinaDepartment of Nephrology The Second Affiliated Hospital of Guangzhou Medical University Guangzhou ChinaDepartment of Nephrology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Nephrology General Hospital of Ningxia Medical University Yinchuan ChinaDepartment of Nephrology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Nephrology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract An imbalance in the serum sodium to chloride ratio (Na/Cl) was linked to higher mortality among heart failure patients. Nonetheless, the prognostic significance of Na/Cl in individuals undergoing peritoneal dialysis (PD) remains unexplored. This study seeks to explore the association between initial Na/Cl levels and mortality in PD patients. The study, conducted across multiple centers, included 3341 patients undergoing PD from January 1, 2005, to December 31, 2021. Patients were stratified into quartiles according to baseline Na/Cl and followed up for a median of 5.77 years. To explore the association between Na/Cl levels and mortality, we employed Cox proportional hazards models, competing risks models, and restricted cubic spline analysis. Of 3341 patients, 722 patients died, including 259 cardiovascular deaths. Following adjustments for comorbidities and multiple covariates, individuals in the highest Na/Cl quartile (>1.42) exhibited lower all‐cause mortality (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.47–0.86) and cardiovascular mortality (HR 0.38, 95% CI 0.22–0.67) compared with those in the lowest quartile (<1.33). A similar pattern was also found when Na/Cl was dealt with continuous variables. Initial levels of Na/Cl at the start of PD were negatively correlated with all‐cause mortality and cardiovascular mortality in PD patients.https://doi.org/10.1002/mco2.70041all‐cause mortalitycardiovascular mortalityperitoneal dialysissodium‐to‐chloride ratio |
| spellingShingle | Jiayin You Sijie Gu Ning Su Xiaoran Feng Fenfen Peng Qingdong Xu Xiaojiang Zhan Yueqiang Wen Xiaoyang Wang Na Tian Xianfeng Wu Niansong Wang Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study MedComm all‐cause mortality cardiovascular mortality peritoneal dialysis sodium‐to‐chloride ratio |
| title | Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study |
| title_full | Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study |
| title_fullStr | Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study |
| title_full_unstemmed | Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study |
| title_short | Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study |
| title_sort | serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis a multicenter retrospective study |
| topic | all‐cause mortality cardiovascular mortality peritoneal dialysis sodium‐to‐chloride ratio |
| url | https://doi.org/10.1002/mco2.70041 |
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