Cell death and cancer: Metabolic interconnections
Summary: Recent findings in the cell death field have transformed our understanding of the interplay between metabolism and cell death in the context of cancer. In this review, we discuss the relationships between metabolism and the cell death pathways of apoptosis, necroptosis, pyroptosis, and ferr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725005753 |
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| author | Destiny Dalseno Nikolai Gajic Lyndsey Flanagan Stephen W.G. Tait |
| author_facet | Destiny Dalseno Nikolai Gajic Lyndsey Flanagan Stephen W.G. Tait |
| author_sort | Destiny Dalseno |
| collection | DOAJ |
| description | Summary: Recent findings in the cell death field have transformed our understanding of the interplay between metabolism and cell death in the context of cancer. In this review, we discuss the relationships between metabolism and the cell death pathways of apoptosis, necroptosis, pyroptosis, and ferroptosis, with a particular focus on recent advancements. We will also explore the regulation of metabolism by the BCL-2 family and the participation of oncometabolites in the regulation of cell death. Finally, we examine the emerging links between cell death signaling and cellular persistence. As we highlight in this review, the intersection of metabolic and cell death pathways has implications for cancer cell survival, treatment resistance, and the tumor microenvironment. |
| format | Article |
| id | doaj-art-844d11ece5f8401780f891799d12b031 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-844d11ece5f8401780f891799d12b0312025-08-20T02:31:11ZengElsevierCell Reports2211-12472025-06-0144611580410.1016/j.celrep.2025.115804Cell death and cancer: Metabolic interconnectionsDestiny Dalseno0Nikolai Gajic1Lyndsey Flanagan2Stephen W.G. Tait3School of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK; Cancer Research UK Scotland Institute, Switchback Road, Glasgow G61 1BD, UK; Corresponding authorSchool of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK; Cancer Research UK Scotland Institute, Switchback Road, Glasgow G61 1BD, UKSchool of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK; Cancer Research UK Scotland Institute, Switchback Road, Glasgow G61 1BD, UKSchool of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK; Cancer Research UK Scotland Institute, Switchback Road, Glasgow G61 1BD, UK; Corresponding authorSummary: Recent findings in the cell death field have transformed our understanding of the interplay between metabolism and cell death in the context of cancer. In this review, we discuss the relationships between metabolism and the cell death pathways of apoptosis, necroptosis, pyroptosis, and ferroptosis, with a particular focus on recent advancements. We will also explore the regulation of metabolism by the BCL-2 family and the participation of oncometabolites in the regulation of cell death. Finally, we examine the emerging links between cell death signaling and cellular persistence. As we highlight in this review, the intersection of metabolic and cell death pathways has implications for cancer cell survival, treatment resistance, and the tumor microenvironment.http://www.sciencedirect.com/science/article/pii/S2211124725005753CP: CancerCP: Metabolism |
| spellingShingle | Destiny Dalseno Nikolai Gajic Lyndsey Flanagan Stephen W.G. Tait Cell death and cancer: Metabolic interconnections Cell Reports CP: Cancer CP: Metabolism |
| title | Cell death and cancer: Metabolic interconnections |
| title_full | Cell death and cancer: Metabolic interconnections |
| title_fullStr | Cell death and cancer: Metabolic interconnections |
| title_full_unstemmed | Cell death and cancer: Metabolic interconnections |
| title_short | Cell death and cancer: Metabolic interconnections |
| title_sort | cell death and cancer metabolic interconnections |
| topic | CP: Cancer CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725005753 |
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