Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience
Background. Kidney transplant recipients (KTRs) are a vulnerable immunocompromised population at risk of severe COVID-19 disease and mortality after SARS-CoV-2 infection. We sought to characterize the post-infection sequelae in KTRs at our center. Methods. We studied all adult KTRs (with a functioni...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/7140548 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553204780367872 |
|---|---|
| author | Emily E. Zona Mina L. Gibes Asha S. Jain Juan S. Danobeitia Jacqueline Garonzik-Wang Jeannina A. Smith Didier A. Mandelbrot Sandesh Parajuli |
| author_facet | Emily E. Zona Mina L. Gibes Asha S. Jain Juan S. Danobeitia Jacqueline Garonzik-Wang Jeannina A. Smith Didier A. Mandelbrot Sandesh Parajuli |
| author_sort | Emily E. Zona |
| collection | DOAJ |
| description | Background. Kidney transplant recipients (KTRs) are a vulnerable immunocompromised population at risk of severe COVID-19 disease and mortality after SARS-CoV-2 infection. We sought to characterize the post-infection sequelae in KTRs at our center. Methods. We studied all adult KTRs (with a functioning allograft) who had their first episode of SARS-CoV-2 infection between 04/2020 and 04/2022. Outcomes of interest included risk factors for hospitalization, all-cause mortality, COVID-19-related mortality, and allograft failure. Results. Of 979 KTRs with SARS-CoV-2 infection, 381 (39%) were hospitalized. In the multivariate analysis, risk factors for hospitalization included advanced age/year (HR: 1.03, 95% CI: 1.02–1.04), male sex (HR: 1.29, 95% CI: 1.04–1.60), non-white race (HR: 1.48, 95% CI: 1.17–1.88), and diabetes as a cause of ESKD (HR: 1.77, 95% CI: 1.41–2.21). SARS-CoV-2 Vaccination was associated with decreased risk of hospitalization (HR: 0.73, 95% CI: 0.59–0.90), all-cause mortality (HR: 0.52, 95% CI: 0.37–0.74), and COVID-19-related mortality (HR: 0.47, 95% CI: 0.31–0.71) in the univariate and multivariate analyses. Risk factors for both all-cause and COVID-19-related mortality in the multivariate analyses included advanced age, hospitalization, and respiratory symptoms for hospital admission. Furthermore, additional risk factors for all-cause mortality in the multivariate analysis included being a non-white recipient and diabetes as a cause of ESKD, with being a recipient of a living donor as protective. Conclusions. Hospitalization due to COVID-19-associated symptoms is associated with increased mortality. Vaccination is a protective factor against hospitalization and mortality. |
| format | Article |
| id | doaj-art-84430add40c944499030003a3fe567c8 |
| institution | Kabale University |
| issn | 2090-1313 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-84430add40c944499030003a3fe567c82025-02-03T05:54:35ZengWileyCritical Care Research and Practice2090-13132024-01-01202410.1155/2024/7140548Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center ExperienceEmily E. Zona0Mina L. Gibes1Asha S. Jain2Juan S. Danobeitia3Jacqueline Garonzik-Wang4Jeannina A. Smith5Didier A. Mandelbrot6Sandesh Parajuli7Division of NephrologyDivision of NephrologyDivision of NephrologyBaylor University Medical CenterDivision of TransplantationDepartment of Infectious DiseaseDivision of NephrologyDivision of NephrologyBackground. Kidney transplant recipients (KTRs) are a vulnerable immunocompromised population at risk of severe COVID-19 disease and mortality after SARS-CoV-2 infection. We sought to characterize the post-infection sequelae in KTRs at our center. Methods. We studied all adult KTRs (with a functioning allograft) who had their first episode of SARS-CoV-2 infection between 04/2020 and 04/2022. Outcomes of interest included risk factors for hospitalization, all-cause mortality, COVID-19-related mortality, and allograft failure. Results. Of 979 KTRs with SARS-CoV-2 infection, 381 (39%) were hospitalized. In the multivariate analysis, risk factors for hospitalization included advanced age/year (HR: 1.03, 95% CI: 1.02–1.04), male sex (HR: 1.29, 95% CI: 1.04–1.60), non-white race (HR: 1.48, 95% CI: 1.17–1.88), and diabetes as a cause of ESKD (HR: 1.77, 95% CI: 1.41–2.21). SARS-CoV-2 Vaccination was associated with decreased risk of hospitalization (HR: 0.73, 95% CI: 0.59–0.90), all-cause mortality (HR: 0.52, 95% CI: 0.37–0.74), and COVID-19-related mortality (HR: 0.47, 95% CI: 0.31–0.71) in the univariate and multivariate analyses. Risk factors for both all-cause and COVID-19-related mortality in the multivariate analyses included advanced age, hospitalization, and respiratory symptoms for hospital admission. Furthermore, additional risk factors for all-cause mortality in the multivariate analysis included being a non-white recipient and diabetes as a cause of ESKD, with being a recipient of a living donor as protective. Conclusions. Hospitalization due to COVID-19-associated symptoms is associated with increased mortality. Vaccination is a protective factor against hospitalization and mortality.http://dx.doi.org/10.1155/2024/7140548 |
| spellingShingle | Emily E. Zona Mina L. Gibes Asha S. Jain Juan S. Danobeitia Jacqueline Garonzik-Wang Jeannina A. Smith Didier A. Mandelbrot Sandesh Parajuli Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience Critical Care Research and Practice |
| title | Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience |
| title_full | Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience |
| title_fullStr | Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience |
| title_full_unstemmed | Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience |
| title_short | Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection among Kidney Transplant Recipients: A Large Single-Center Experience |
| title_sort | sequelae of severe acute respiratory syndrome coronavirus 2 sars cov 2 infection among kidney transplant recipients a large single center experience |
| url | http://dx.doi.org/10.1155/2024/7140548 |
| work_keys_str_mv | AT emilyezona sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT minalgibes sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT ashasjain sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT juansdanobeitia sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT jacquelinegaronzikwang sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT jeanninaasmith sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT didieramandelbrot sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience AT sandeshparajuli sequelaeofsevereacuterespiratorysyndromecoronavirus2sarscov2infectionamongkidneytransplantrecipientsalargesinglecenterexperience |