Structure guided functional analysis of the S. cerevisiae Mre11 complex

Structure guided functional analysis of the S. cerevisiae Mre11 complex

Abstract The Mre11 complex comprises Mre11, Rad50 and Nbs1 (Xrs2 in S. cerevisiae). The core components, Mre11 and Rad50 are highly conserved, with readily identifiable orthologs in all clades of life, whereas Nbs1/Xrs2 are present only in eukaryotes. In eukaryotes, the complex is integral to the DN...

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Main Authors: Marcel Hohl, You Yu, Vitaly Kuryavyi, Dinshaw J. Patel, John Petrini
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62583-3
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