Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives
Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechan...
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| Format: | Article |
| Language: | fas |
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Iran Air Force Health Administration
2019-12-01
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| Series: | فصلنامه ابن سینا |
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| Online Access: | http://ebnesina.ajaums.ac.ir/article-1-695-en.pdf |
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| author | Abolfazl Khademi Zahra Jahanbakhsh Mitra Yousefpour Afsaneh Karami Juyani |
| author_facet | Abolfazl Khademi Zahra Jahanbakhsh Mitra Yousefpour Afsaneh Karami Juyani |
| author_sort | Abolfazl Khademi |
| collection | DOAJ |
| description | Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechanisms of the protective effects of chronic hypoxia. Studies in the past decades and recent genomic studies have suggested a genetic basis for these physiological adaptations in these areas. It is also known that patterns of genetic variations are different among major populations of high altitudes. This article is a review of the physiological adaptations to chronic hypoxia and its molecular and genetic mechanisms. |
| format | Article |
| id | doaj-art-843c86323fa1459cb914efb2e93d3bae |
| institution | DOAJ |
| issn | 1735-9503 2645-4653 |
| language | fas |
| publishDate | 2019-12-01 |
| publisher | Iran Air Force Health Administration |
| record_format | Article |
| series | فصلنامه ابن سینا |
| spelling | doaj-art-843c86323fa1459cb914efb2e93d3bae2025-08-20T02:47:05ZfasIran Air Force Health Administrationفصلنامه ابن سینا1735-95032645-46532019-12-012145973Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude nativesAbolfazl Khademi0Zahra Jahanbakhsh1Mitra Yousefpour2Afsaneh Karami Juyani3 Faculty of Aerospace and Subaquatic Medicine, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran Faculty of Aerospace and Subaquatic Medicine, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran Department of Physiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechanisms of the protective effects of chronic hypoxia. Studies in the past decades and recent genomic studies have suggested a genetic basis for these physiological adaptations in these areas. It is also known that patterns of genetic variations are different among major populations of high altitudes. This article is a review of the physiological adaptations to chronic hypoxia and its molecular and genetic mechanisms.http://ebnesina.ajaums.ac.ir/article-1-695-en.pdfphysiological adaptationaltitude hypoxiagenetic variation |
| spellingShingle | Abolfazl Khademi Zahra Jahanbakhsh Mitra Yousefpour Afsaneh Karami Juyani Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives فصلنامه ابن سینا physiological adaptation altitude hypoxia genetic variation |
| title | Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives |
| title_full | Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives |
| title_fullStr | Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives |
| title_full_unstemmed | Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives |
| title_short | Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives |
| title_sort | molecular and genetic mechanisms of physiological adaptations in high altitude natives molecular and genetic mechanisms of physiological adaptations in high altitude natives |
| topic | physiological adaptation altitude hypoxia genetic variation |
| url | http://ebnesina.ajaums.ac.ir/article-1-695-en.pdf |
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