E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus

E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus

Abstract Since 2021, the novel H10N3 has caused four cases of human infection in China, the most recent of which occurred in December 2024, posing a potential threat to public health. Our previous studies indicated that several avian H10N3 strains are highly pathogenic in mice and can be transmitted...

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Main Authors: Meishan Song, Jianyu Liang, Sige Wang, Ruyi Gao, Xiaolong Lu, Wenhao Yang, Yu Chen, Jingxia Ma, Min Gu, Jiao Hu, Xiaowen Liu, Shunlin Hu, Xiaoquan Wang, Kaituo Liu, Xiufan Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Veterinary Research
Subjects:
Avian influenza virus
novel H10N3
mammal adaption
PB2-E627V/K
Online Access:https://doi.org/10.1186/s13567-025-01534-8
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