Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis
Breast cancer is the most commonly diagnosed cancer worldwide, with early detection and advanced treatments contributing to declining mortality rates. However, managing comorbid conditions, particularly mental illness, presents significant challenges for cancer treatment. This study systematically r...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Breast |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856914831769600 |
|---|---|
| author | Katie Elliott Emily Haworth Iakov Bolnykh R. Hamish McAllister-Williams Alastair Greystoke Adam Todd Linda Sharp |
| author_facet | Katie Elliott Emily Haworth Iakov Bolnykh R. Hamish McAllister-Williams Alastair Greystoke Adam Todd Linda Sharp |
| author_sort | Katie Elliott |
| collection | DOAJ |
| description | Breast cancer is the most commonly diagnosed cancer worldwide, with early detection and advanced treatments contributing to declining mortality rates. However, managing comorbid conditions, particularly mental illness, presents significant challenges for cancer treatment. This study systematically reviews and meta-analyses the impact of having a pre-existing mental illness on breast cancer treatment utilisation, focusing on specific treatments and comparing different mental illnesses. MEDLINE, EMBASE, CINAHL, and APA PsycInfo databases were searched. After screening, fifteen studies were identified as meeting the inclusion criteria. The included studies were predominantly from high-income countries, and compared breast cancer treatment in patients with and without pre-existing mental illnesses including anxiety, mood disorders, schizophrenia and psychotic disorders, and neurodevelopmental disorders. Meta-analysis revealed that patients with mental illnesses were significantly less likely to receive guideline-recommended treatments (OR = 0.78, 95 % CI 0.72–0.83, N = 5), chemotherapy (OR = 0.56, 95 % CI 0.34–0.78, N = 6), or radiotherapy (OR = 0.79, 95 % CI 0.66–0.93, N = 5). They were also significantly more likely to undergo mastectomy instead of breast-conserving surgery (OR = 1.38, 95 % CI 1.24–1.52, N = 4). Findings were consistent across different mental illnesses. This review highlights the need for targeted interventions to improve healthcare access and address provider biases, promoting better integration of mental health and oncology care. |
| format | Article |
| id | doaj-art-84398b3c3dec45ec83d1fd040f8a7e3e |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-84398b3c3dec45ec83d1fd040f8a7e3e2025-02-12T05:30:35ZengElsevierBreast1532-30802025-02-0179103855Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysisKatie Elliott0Emily Haworth1Iakov Bolnykh2R. Hamish McAllister-Williams3Alastair Greystoke4Adam Todd5Linda Sharp6Population Health Sciences Institute, Newcastle University, Newcastle University Centre for Cancer, Newcastle upon Tyne, England, UKPopulation Health Sciences Institute, Newcastle University, Newcastle University Centre for Cancer, Newcastle upon Tyne, England, UKPopulation Health Sciences Institute, Newcastle University, Newcastle University Centre for Cancer, Newcastle upon Tyne, England, UKCumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK; Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK; School of Pharmacy, Newcastle University, Newcastle Upon Tyne, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UKSchool of Pharmacy, Newcastle University, Newcastle Upon Tyne, UKPopulation Health Sciences Institute, Newcastle University, Newcastle University Centre for Cancer, Newcastle upon Tyne, England, UK; Corresponding author. Ridley 1 Building, Newcastle University, Claremont Road, Newcastle upon Tyne, NE1 7RU, UK.Breast cancer is the most commonly diagnosed cancer worldwide, with early detection and advanced treatments contributing to declining mortality rates. However, managing comorbid conditions, particularly mental illness, presents significant challenges for cancer treatment. This study systematically reviews and meta-analyses the impact of having a pre-existing mental illness on breast cancer treatment utilisation, focusing on specific treatments and comparing different mental illnesses. MEDLINE, EMBASE, CINAHL, and APA PsycInfo databases were searched. After screening, fifteen studies were identified as meeting the inclusion criteria. The included studies were predominantly from high-income countries, and compared breast cancer treatment in patients with and without pre-existing mental illnesses including anxiety, mood disorders, schizophrenia and psychotic disorders, and neurodevelopmental disorders. Meta-analysis revealed that patients with mental illnesses were significantly less likely to receive guideline-recommended treatments (OR = 0.78, 95 % CI 0.72–0.83, N = 5), chemotherapy (OR = 0.56, 95 % CI 0.34–0.78, N = 6), or radiotherapy (OR = 0.79, 95 % CI 0.66–0.93, N = 5). They were also significantly more likely to undergo mastectomy instead of breast-conserving surgery (OR = 1.38, 95 % CI 1.24–1.52, N = 4). Findings were consistent across different mental illnesses. This review highlights the need for targeted interventions to improve healthcare access and address provider biases, promoting better integration of mental health and oncology care.http://www.sciencedirect.com/science/article/pii/S0960977624001863Breast cancerTreatmentMental illnessHealth disparitiesComorbid conditionsOncology |
| spellingShingle | Katie Elliott Emily Haworth Iakov Bolnykh R. Hamish McAllister-Williams Alastair Greystoke Adam Todd Linda Sharp Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis Breast Breast cancer Treatment Mental illness Health disparities Comorbid conditions Oncology |
| title | Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis |
| title_full | Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis |
| title_fullStr | Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis |
| title_full_unstemmed | Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis |
| title_short | Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis |
| title_sort | breast cancer patients with a pre existing mental illness are less likely to receive guideline recommended cancer treatment a systematic review and meta analysis |
| topic | Breast cancer Treatment Mental illness Health disparities Comorbid conditions Oncology |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001863 |
| work_keys_str_mv | AT katieelliott breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT emilyhaworth breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT iakovbolnykh breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT rhamishmcallisterwilliams breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT alastairgreystoke breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT adamtodd breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis AT lindasharp breastcancerpatientswithapreexistingmentalillnessarelesslikelytoreceiveguidelinerecommendedcancertreatmentasystematicreviewandmetaanalysis |