Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention
Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological and pathological processes, such as inflammation, tissue injury, cardiovascular diseases, t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2025-03-01
|
| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824001481 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849387915062280192 |
|---|---|
| author | Lanya Li Fei Wang Dashuai Zhu Shiqi Hu Ke Cheng Zhenhua Li |
| author_facet | Lanya Li Fei Wang Dashuai Zhu Shiqi Hu Ke Cheng Zhenhua Li |
| author_sort | Lanya Li |
| collection | DOAJ |
| description | Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological and pathological processes, such as inflammation, tissue injury, cardiovascular diseases, tumorigenesis and tumor development. Exosomes have exhibited promising results in the diagnosis and treatment of cancer, cardiovascular diseases and others. They are a rapidly growing class of drug delivery vehicles with many advantages over conventional synthetic carriers. Exosomes used in therapeutic applications encounter several challenges, such as the lack of tissue targeting capabilities and short residence time. In this review, we discuss recent advances in exosome engineering to improve tissue targeting and describe the current types of engineered exosome-like nanovesicles, and summarize their preclinical applications in the treatment of diseases. Further, we also highlight the latest engineering strategies developed to extend exosomes retention time in vivo and exosome-like nanovesicles. |
| format | Article |
| id | doaj-art-842fd0175ca9457fa7ad7f7bf0e1b848 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-842fd0175ca9457fa7ad7f7bf0e1b8482025-08-20T03:42:27ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-03-015285186710.1016/j.fmre.2024.03.025Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retentionLanya Li0Fei Wang1Dashuai Zhu2Shiqi Hu3Ke Cheng4Zhenhua Li5The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Southern Medical University, Guangdong 510515, ChinaThe Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Southern Medical University, Guangdong 510515, ChinaDepartment of Biomedical Engineering, Columbia University, New York 10032, USADepartment of Biomedical Engineering, Columbia University, New York 10032, USADepartment of Biomedical Engineering, Columbia University, New York 10032, USA; Corresponding authors.The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Southern Medical University, Guangdong 510515, China; Corresponding authors.Exosomes are natural nano-size particles secreted by human cells, containing numerous bioactive cargos. Serving as crucial mediators of intercellular communication, exosomes are involved in many physiological and pathological processes, such as inflammation, tissue injury, cardiovascular diseases, tumorigenesis and tumor development. Exosomes have exhibited promising results in the diagnosis and treatment of cancer, cardiovascular diseases and others. They are a rapidly growing class of drug delivery vehicles with many advantages over conventional synthetic carriers. Exosomes used in therapeutic applications encounter several challenges, such as the lack of tissue targeting capabilities and short residence time. In this review, we discuss recent advances in exosome engineering to improve tissue targeting and describe the current types of engineered exosome-like nanovesicles, and summarize their preclinical applications in the treatment of diseases. Further, we also highlight the latest engineering strategies developed to extend exosomes retention time in vivo and exosome-like nanovesicles.http://www.sciencedirect.com/science/article/pii/S2667325824001481ExosomesExosome-like nanovesiclesEngineeringTargetingRetention |
| spellingShingle | Lanya Li Fei Wang Dashuai Zhu Shiqi Hu Ke Cheng Zhenhua Li Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention Fundamental Research Exosomes Exosome-like nanovesicles Engineering Targeting Retention |
| title | Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention |
| title_full | Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention |
| title_fullStr | Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention |
| title_full_unstemmed | Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention |
| title_short | Engineering exosomes and exosome-like nanovesicles for improving tissue targeting and retention |
| title_sort | engineering exosomes and exosome like nanovesicles for improving tissue targeting and retention |
| topic | Exosomes Exosome-like nanovesicles Engineering Targeting Retention |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824001481 |
| work_keys_str_mv | AT lanyali engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention AT feiwang engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention AT dashuaizhu engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention AT shiqihu engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention AT kecheng engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention AT zhenhuali engineeringexosomesandexosomelikenanovesiclesforimprovingtissuetargetingandretention |