Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study

Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study

Abstract Background Bipolar disorder (BD) is a heterogeneous psychiatric condition characterized by distinct episodes: manic (BipM), depressive (BipD), mixed (mBD), and remission (rBD). Current evidence indicates alterations in brain functional connectivity in BD, yet a comprehensive understanding a...

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Main Authors: Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Bipolar disorder
Episode states
Functional gradients
Functional integration and segregation
Signal flow
Receptor and cellular maps
Online Access:https://doi.org/10.1186/s12916-025-04277-7
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