Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution
Background. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients. Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2015/742573 |
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| author | Adetola Olubunmi Daramola Mosebolatan Olatokunboh Odubanjo Fred John Obiajulu Nzechukwu Zimudo Ikeri Adekunbiola Aina Fehintola Banjo |
| author_facet | Adetola Olubunmi Daramola Mosebolatan Olatokunboh Odubanjo Fred John Obiajulu Nzechukwu Zimudo Ikeri Adekunbiola Aina Fehintola Banjo |
| author_sort | Adetola Olubunmi Daramola |
| collection | DOAJ |
| description | Background. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients. Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period. Methods. The findings obtained from FNAC of palpable breast lumps seen at the FNAC clinic of our department from January 2007 to December 2011 were retrieved and correlated with findings on histology of excisional biopsies. Results. A total of 1790 patients had FNAC of breast lumps during the 5-year period; 436 of them subsequently had biopsies. Our results compare favourably with the measures of test performance of the UK NHS Breast Screening Programme shown in brackets: absolute sensitivity 95.4% (>70%), complete sensitivity 99.2% (>90%), full specificity 88.9% (>65%), positive predictive value 99.6% (>99%), false-negative rate 0.8% (<4%), false-positive rate 0.4% (<0.5%), inadequate rate 3.2% (<15%), and suspicious rate 10.2% (<15%). Conclusion. Breast FNACs compare very well with histology of excisional biopsies and in experienced hands are extremely useful in the management of breast lumps. Further studies assessing the diagnostic accuracy of FNAC and cell blocks in our setting are recommended. |
| format | Article |
| id | doaj-art-842be2d257cb44c7a2e71ae596b9a3a8 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-842be2d257cb44c7a2e71ae596b9a3a82025-02-03T01:21:18ZengWileyInternational Journal of Breast Cancer2090-31702090-31892015-01-01201510.1155/2015/742573742573Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health InstitutionAdetola Olubunmi Daramola0Mosebolatan Olatokunboh Odubanjo1Fred John Obiajulu2Nzechukwu Zimudo Ikeri3Adekunbiola Aina Fehintola Banjo4Department of Anatomic and Molecular Pathology, Lagos University Teaching Hospital and College of Medicine, University of Lagos, PMB 12003, Idi-Araba, Lagos, NigeriaDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital and College of Medicine, University of Lagos, PMB 12003, Idi-Araba, Lagos, NigeriaDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, PMB 12003, Idi-Araba, Lagos, NigeriaDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, PMB 12003, Idi-Araba, Lagos, NigeriaDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital and College of Medicine, University of Lagos, PMB 12003, Idi-Araba, Lagos, NigeriaBackground. Management of breast lumps can be challenging in resource poor settings. Fine-needle aspiration cytology (FNAC) especially when used with cell block can help improve affordability for the patients. Objective. To determine the diagnostic accuracy of FNAC of palpable breast lesions within a 5-year period. Methods. The findings obtained from FNAC of palpable breast lumps seen at the FNAC clinic of our department from January 2007 to December 2011 were retrieved and correlated with findings on histology of excisional biopsies. Results. A total of 1790 patients had FNAC of breast lumps during the 5-year period; 436 of them subsequently had biopsies. Our results compare favourably with the measures of test performance of the UK NHS Breast Screening Programme shown in brackets: absolute sensitivity 95.4% (>70%), complete sensitivity 99.2% (>90%), full specificity 88.9% (>65%), positive predictive value 99.6% (>99%), false-negative rate 0.8% (<4%), false-positive rate 0.4% (<0.5%), inadequate rate 3.2% (<15%), and suspicious rate 10.2% (<15%). Conclusion. Breast FNACs compare very well with histology of excisional biopsies and in experienced hands are extremely useful in the management of breast lumps. Further studies assessing the diagnostic accuracy of FNAC and cell blocks in our setting are recommended.http://dx.doi.org/10.1155/2015/742573 |
| spellingShingle | Adetola Olubunmi Daramola Mosebolatan Olatokunboh Odubanjo Fred John Obiajulu Nzechukwu Zimudo Ikeri Adekunbiola Aina Fehintola Banjo Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution International Journal of Breast Cancer |
| title | Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution |
| title_full | Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution |
| title_fullStr | Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution |
| title_full_unstemmed | Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution |
| title_short | Correlation between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution |
| title_sort | correlation between fine needle aspiration cytology and histology for palpable breast masses in a nigerian tertiary health institution |
| url | http://dx.doi.org/10.1155/2015/742573 |
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