A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review
Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. Despite advancements in neuroimaging and surgical techniques, their management remains complex due to their location near critical...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/1/41 |
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| author | Manuel De Jesus Encarnacion Ramirez Gervith Reyes Soto Carlos Castillo Rangel |
| author_facet | Manuel De Jesus Encarnacion Ramirez Gervith Reyes Soto Carlos Castillo Rangel |
| author_sort | Manuel De Jesus Encarnacion Ramirez |
| collection | DOAJ |
| description | Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. Despite advancements in neuroimaging and surgical techniques, their management remains complex due to their location near critical cognitive areas. Techniques like awake craniotomy have improved outcomes, but tumor heterogeneity and proximity to vital structures pose challenges. Radiotherapy and chemotherapy offer benefits post-surgery, though issues like resistance and side effects persist. This article discusses a case report and literature review to deepen understanding of temporo-insular gliomas, focusing on advanced diagnostic and treatment approaches. Materials and Methods: A systematic review was conducted using PubMed, Embase, and Google Scholar, covering studies from 2019 to July 2024. Keywords included ‘brain tumor’, ‘neurosurgery’, and ‘treatment’. Articles on glioma diagnosis, management, and outcomes were selected, excluding non-English studies, irrelevant reports, non-glioma research, and inaccessible texts. Results: From 156 studies, 11 met inclusion criteria, highlighting advanced diagnostics, surgical strategies, and adjunct therapies for temporo-insular gliomas (TIGs). Gross total resection (GTR) was achieved in 39% of cases. Awake craniotomy enhanced functional outcomes, while temozolomide and radiotherapy improved survival. Challenges included ischemic complications and treatment resistance. Two patient cases underscored the complexity of TIG management and the importance of individualized approaches, achieving satisfactory resection with minimal deficits. Conclusions: Temporo-insular gliomas (TIGs) necessitate a multidisciplinary strategy that integrates advanced imaging, meticulous surgical methods, and cutting-edge adjuvant therapies. Despite progress with techniques like awake craniotomy and the use of temozolomide improving patient outcomes, significant challenges persist in maintaining functional integrity and addressing treatment resistance. Ongoing research into targeted therapies, immunotherapies, and innovative technologies remains critical to advancing patient care and improving long-term prognosis. |
| format | Article |
| id | doaj-art-842bce9b437145738630bb5a79835822 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-842bce9b437145738630bb5a798358222025-01-24T13:28:27ZengMDPI AGCurrent Oncology1198-00521718-77292025-01-013214110.3390/curroncol32010041A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature ReviewManuel De Jesus Encarnacion Ramirez0Gervith Reyes Soto1Carlos Castillo Rangel2Neurological Surgery, Peoples Friendship University of Russia, 117198 Moscow, RussiaNeurosciencce Departament, Mexico’s National Institute of Cancer, Mexico City 14080, MexicoNeurosurgery Departament at ISSSTE 1ero De Octubre, Mexico City 07760, MexicoIntroduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. Despite advancements in neuroimaging and surgical techniques, their management remains complex due to their location near critical cognitive areas. Techniques like awake craniotomy have improved outcomes, but tumor heterogeneity and proximity to vital structures pose challenges. Radiotherapy and chemotherapy offer benefits post-surgery, though issues like resistance and side effects persist. This article discusses a case report and literature review to deepen understanding of temporo-insular gliomas, focusing on advanced diagnostic and treatment approaches. Materials and Methods: A systematic review was conducted using PubMed, Embase, and Google Scholar, covering studies from 2019 to July 2024. Keywords included ‘brain tumor’, ‘neurosurgery’, and ‘treatment’. Articles on glioma diagnosis, management, and outcomes were selected, excluding non-English studies, irrelevant reports, non-glioma research, and inaccessible texts. Results: From 156 studies, 11 met inclusion criteria, highlighting advanced diagnostics, surgical strategies, and adjunct therapies for temporo-insular gliomas (TIGs). Gross total resection (GTR) was achieved in 39% of cases. Awake craniotomy enhanced functional outcomes, while temozolomide and radiotherapy improved survival. Challenges included ischemic complications and treatment resistance. Two patient cases underscored the complexity of TIG management and the importance of individualized approaches, achieving satisfactory resection with minimal deficits. Conclusions: Temporo-insular gliomas (TIGs) necessitate a multidisciplinary strategy that integrates advanced imaging, meticulous surgical methods, and cutting-edge adjuvant therapies. Despite progress with techniques like awake craniotomy and the use of temozolomide improving patient outcomes, significant challenges persist in maintaining functional integrity and addressing treatment resistance. Ongoing research into targeted therapies, immunotherapies, and innovative technologies remains critical to advancing patient care and improving long-term prognosis.https://www.mdpi.com/1718-7729/32/1/41gliomatemporo-insular |
| spellingShingle | Manuel De Jesus Encarnacion Ramirez Gervith Reyes Soto Carlos Castillo Rangel A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review Current Oncology glioma temporo-insular |
| title | A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review |
| title_full | A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review |
| title_fullStr | A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review |
| title_full_unstemmed | A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review |
| title_short | A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review |
| title_sort | journey into the complexity of temporo insular gliomas case report and literature review |
| topic | glioma temporo-insular |
| url | https://www.mdpi.com/1718-7729/32/1/41 |
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