Lipid-Induced Mechanisms of Metabolic Syndrome
Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2020/5762395 |
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| author | Yulia K. Denisenko Oxana Yu Kytikova Tatyana P. Novgorodtseva Marina V. Antonyuk Tatyana A. Gvozdenko Tatyana A. Kantur |
| author_facet | Yulia K. Denisenko Oxana Yu Kytikova Tatyana P. Novgorodtseva Marina V. Antonyuk Tatyana A. Gvozdenko Tatyana A. Kantur |
| author_sort | Yulia K. Denisenko |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS. |
| format | Article |
| id | doaj-art-842355fd4bb94633a52ff508f263a0b4 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-842355fd4bb94633a52ff508f263a0b42025-02-03T06:43:50ZengWileyJournal of Obesity2090-07082090-07162020-01-01202010.1155/2020/57623955762395Lipid-Induced Mechanisms of Metabolic SyndromeYulia K. Denisenko0Oxana Yu Kytikova1Tatyana P. Novgorodtseva2Marina V. Antonyuk3Tatyana A. Gvozdenko4Tatyana A. Kantur5Vladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok 690105, RussiaVladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok 690105, RussiaVladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok 690105, RussiaVladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok 690105, RussiaVladivostok Branch of the Far Eastern Scientific Centre of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok 690105, RussiaFar Eastern Federal University, Vladivostok 690950, RussiaMetabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.http://dx.doi.org/10.1155/2020/5762395 |
| spellingShingle | Yulia K. Denisenko Oxana Yu Kytikova Tatyana P. Novgorodtseva Marina V. Antonyuk Tatyana A. Gvozdenko Tatyana A. Kantur Lipid-Induced Mechanisms of Metabolic Syndrome Journal of Obesity |
| title | Lipid-Induced Mechanisms of Metabolic Syndrome |
| title_full | Lipid-Induced Mechanisms of Metabolic Syndrome |
| title_fullStr | Lipid-Induced Mechanisms of Metabolic Syndrome |
| title_full_unstemmed | Lipid-Induced Mechanisms of Metabolic Syndrome |
| title_short | Lipid-Induced Mechanisms of Metabolic Syndrome |
| title_sort | lipid induced mechanisms of metabolic syndrome |
| url | http://dx.doi.org/10.1155/2020/5762395 |
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