Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation

Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation

Abstract To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate by utilizing energy provided by oxidative pho...

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Main Authors: Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty, Jeannie M. Camarillo, David Barry, Roger George, Neil P. Blackledge, Graham Duddy, Neil L. Kelleher, Robert J. Klose, Martin Turner, Dinis P. Calado
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54937-0
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