Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy
Abstract Photodynamic immunotherapy which combines photodynamic therapy with immunotherapy has become an important and effective method for the treatment of cancer. However, most cancer photodynamic immunotherapeutic systems are not able to achieve precise release of immunomodulators, resulting in s...
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| Format: | Article |
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409833 |
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| author | Shanchao Diao Zhifan Zhang Sijun Zhao Qiang Li Xiaolong Zhang Xiangqi Yang Zhiwei Xu Mingming Liu Wen Zhou Rutian Li Chen Xie Quli Fan |
| author_facet | Shanchao Diao Zhifan Zhang Sijun Zhao Qiang Li Xiaolong Zhang Xiangqi Yang Zhiwei Xu Mingming Liu Wen Zhou Rutian Li Chen Xie Quli Fan |
| author_sort | Shanchao Diao |
| collection | DOAJ |
| description | Abstract Photodynamic immunotherapy which combines photodynamic therapy with immunotherapy has become an important and effective method for the treatment of cancer. However, most cancer photodynamic immunotherapeutic systems are not able to achieve precise release of immunomodulators, resulting in systemic side effects and poor patient outcomes. Herein, a dual‐activatable nano‐immunomodulator (DIR NP), which both its photodynamic effect and agonist release can be activated under specific stimuli, is reported for precision cancer photodynamic immunotherapy. The DIR NP is self‐assembled from an R848‐conjugated amphiphilic polymer (mPEG‐TK‐R848) and a hydrophobic oxidized bovine serum albumin (BSA‐SOH)‐conjugatable photosensitizer (DIR). DIR NPs may generate a small amount of 1O2 under 808 nm laser irradiation, leading to the cleavage of thioketal (TK) moiety and release of R848 and DIR. The released DIR may conjugate with tumor‐overexpressed BSA‐SOH, improving its photodynamic efficiency and NIR‐II fluorescence signal. Such photodynamic efficiency improvement may further enhance the release of cargoes upon irradiation. The activated photodynamic effect induces immunogenic cell death (ICD) to release immune factors and R848 can enhance the maturation of dendritic cells for inhibiting the growth of both primary and distant tumors and eliminating lung metastasis. Therefore, this study provides a dual‐activatable intelligent nano‐immunomodulator for precise regulation of tumor photodynamic immunotherapy. |
| format | Article |
| id | doaj-art-841ccf4dfb3f403ca5e24887432c5c8d |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-841ccf4dfb3f403ca5e24887432c5c8d2025-08-20T02:19:01ZengWileyAdvanced Science2198-38442024-12-011145n/an/a10.1002/advs.202409833Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic ImmunotherapyShanchao Diao0Zhifan Zhang1Sijun Zhao2Qiang Li3Xiaolong Zhang4Xiangqi Yang5Zhiwei Xu6Mingming Liu7Wen Zhou8Rutian Li9Chen Xie10Quli Fan11State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaThe Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School Nanjing University Nanjing 210008 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaThe Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School Nanjing University Nanjing 210008 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications 9 Wenyuan Road Nanjing 210023 ChinaAbstract Photodynamic immunotherapy which combines photodynamic therapy with immunotherapy has become an important and effective method for the treatment of cancer. However, most cancer photodynamic immunotherapeutic systems are not able to achieve precise release of immunomodulators, resulting in systemic side effects and poor patient outcomes. Herein, a dual‐activatable nano‐immunomodulator (DIR NP), which both its photodynamic effect and agonist release can be activated under specific stimuli, is reported for precision cancer photodynamic immunotherapy. The DIR NP is self‐assembled from an R848‐conjugated amphiphilic polymer (mPEG‐TK‐R848) and a hydrophobic oxidized bovine serum albumin (BSA‐SOH)‐conjugatable photosensitizer (DIR). DIR NPs may generate a small amount of 1O2 under 808 nm laser irradiation, leading to the cleavage of thioketal (TK) moiety and release of R848 and DIR. The released DIR may conjugate with tumor‐overexpressed BSA‐SOH, improving its photodynamic efficiency and NIR‐II fluorescence signal. Such photodynamic efficiency improvement may further enhance the release of cargoes upon irradiation. The activated photodynamic effect induces immunogenic cell death (ICD) to release immune factors and R848 can enhance the maturation of dendritic cells for inhibiting the growth of both primary and distant tumors and eliminating lung metastasis. Therefore, this study provides a dual‐activatable intelligent nano‐immunomodulator for precise regulation of tumor photodynamic immunotherapy.https://doi.org/10.1002/advs.202409833NIR‐II fluorescence imagingphoto‐activationphotodynamic therapyphotoimmunotherapyphototheranostics |
| spellingShingle | Shanchao Diao Zhifan Zhang Sijun Zhao Qiang Li Xiaolong Zhang Xiangqi Yang Zhiwei Xu Mingming Liu Wen Zhou Rutian Li Chen Xie Quli Fan Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy Advanced Science NIR‐II fluorescence imaging photo‐activation photodynamic therapy photoimmunotherapy phototheranostics |
| title | Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy |
| title_full | Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy |
| title_fullStr | Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy |
| title_full_unstemmed | Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy |
| title_short | Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy |
| title_sort | dual activatable nano immunomodulator for nir ii fluorescence imaging guided precision cancer photodynamic immunotherapy |
| topic | NIR‐II fluorescence imaging photo‐activation photodynamic therapy photoimmunotherapy phototheranostics |
| url | https://doi.org/10.1002/advs.202409833 |
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