Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes
Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother’s offspring. Clostridium butyricum, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system’s development...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-05-01
|
| Series: | Immunological Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2025.2504021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849730613346566144 |
|---|---|
| author | Celeste Peterson Aili Tagoma Kristi Alnek Anu Bärenson Tamara Vorobjova Ija Talja Helis Janson Anne Kirss Siiri Kõljalg Aki Sinkkonen Marja Irmeli Roslund Raivo Uibo |
| author_facet | Celeste Peterson Aili Tagoma Kristi Alnek Anu Bärenson Tamara Vorobjova Ija Talja Helis Janson Anne Kirss Siiri Kõljalg Aki Sinkkonen Marja Irmeli Roslund Raivo Uibo |
| author_sort | Celeste Peterson |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother’s offspring. Clostridium butyricum, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system’s development in the offspring of mothers with GDM. This study assessed antibody responses against C. butyricum T2F3 in children of mothers at risk for GDM, involving 88 children aged 1–6 years. Antibody responses were measured with flow cytometry and immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG bands against C. butyricum were detected in children of mothers with GDM. Maternal body mass index was positively associated with children’s IgG MFI and number of IgG bands. Fewer IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate that maternal prenatal changes could affect their offspring’s immune response against C. butyricum. Moreover, C. butyricum could have a protective role against allergic sensitization. |
| format | Article |
| id | doaj-art-84188bc8dbda40a5a085f9641bfe1110 |
| institution | DOAJ |
| issn | 2578-5826 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj-art-84188bc8dbda40a5a085f9641bfe11102025-08-20T03:08:48ZengTaylor & Francis GroupImmunological Medicine2578-58262025-05-0111110.1080/25785826.2025.2504021Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetesCeleste Peterson0Aili Tagoma1Kristi Alnek2Anu Bärenson3Tamara Vorobjova4Ija Talja5Helis Janson6Anne Kirss7Siiri Kõljalg8Aki Sinkkonen9Marja Irmeli Roslund10Raivo Uibo11Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaWomen’s Clinic, Tartu University Hospital, Tartu, EstoniaDepartment of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaHorticulture Technologies, Natural Resources Institute Finland, Turku, FinlandHorticulture Technologies, Natural Resources Institute Finland, Turku, FinlandDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, EstoniaGestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition, which can be transferred to the mother’s offspring. Clostridium butyricum, known for its health benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune system’s development in the offspring of mothers with GDM. This study assessed antibody responses against C. butyricum T2F3 in children of mothers at risk for GDM, involving 88 children aged 1–6 years. Antibody responses were measured with flow cytometry and immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG bands against C. butyricum were detected in children of mothers with GDM. Maternal body mass index was positively associated with children’s IgG MFI and number of IgG bands. Fewer IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate that maternal prenatal changes could affect their offspring’s immune response against C. butyricum. Moreover, C. butyricum could have a protective role against allergic sensitization.https://www.tandfonline.com/doi/10.1080/25785826.2025.2504021Clostridium butyricumgestational diabetes mellitusatopic dermatitisasthmaantibody |
| spellingShingle | Celeste Peterson Aili Tagoma Kristi Alnek Anu Bärenson Tamara Vorobjova Ija Talja Helis Janson Anne Kirss Siiri Kõljalg Aki Sinkkonen Marja Irmeli Roslund Raivo Uibo Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes Immunological Medicine Clostridium butyricum gestational diabetes mellitus atopic dermatitis asthma antibody |
| title | Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes |
| title_full | Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes |
| title_fullStr | Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes |
| title_full_unstemmed | Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes |
| title_short | Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes |
| title_sort | antibodies against clostridium butyricum in the children of mothers at risk for gestational diabetes |
| topic | Clostridium butyricum gestational diabetes mellitus atopic dermatitis asthma antibody |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2025.2504021 |
| work_keys_str_mv | AT celestepeterson antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT ailitagoma antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT kristialnek antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT anubarenson antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT tamaravorobjova antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT ijatalja antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT helisjanson antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT annekirss antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT siirikoljalg antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT akisinkkonen antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT marjairmeliroslund antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes AT raivouibo antibodiesagainstclostridiumbutyricuminthechildrenofmothersatriskforgestationaldiabetes |