Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive dysfunction that affects millions of people worldwide, placing a massive burden on families and economies. Exercise training can effectively reduce the prevalence of AD and alleviate its sy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1558078/full |
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| author | Jihe Kang Mei Liu Qiang Yang Xiangji Dang Qun Li Ting Wang Bin Qiu Yibao Zhang Xudong Guo Xiaoling Li Yan Liu |
| author_facet | Jihe Kang Mei Liu Qiang Yang Xiangji Dang Qun Li Ting Wang Bin Qiu Yibao Zhang Xudong Guo Xiaoling Li Yan Liu |
| author_sort | Jihe Kang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive dysfunction that affects millions of people worldwide, placing a massive burden on families and economies. Exercise training can effectively reduce the prevalence of AD and alleviate its symptoms through the modulation of multiple signaling pathways involved in the pathophysiological process of AD, including the PI3K/Akt, Wnt/β-catenin, AMPK-related, MAPK, NF-κB, PINK1-PARKIN, JAK/STAT, and TREM2 signaling pathways. Different signaling pathways also crosstalk with each other through different targets to inhibit the formation of Amyloid β (Aβ) plaques, reduce the level of hyperphosphorylated tau protein, reduce apoptosis, relieve neuroinflammation, reduce autophagy dysfunction, and ultimately improve cognitive impairment in AD patients. This review summarizes the pathophysiological processes of AD affected by exercise training through different signaling pathways. We further provide a reference for the future development of new effective AD prevention and treatment targets to develop promising personalized, combined intervention strategies. |
| format | Article |
| id | doaj-art-841615946b8d4ce8b99d76f256ab22f5 |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-841615946b8d4ce8b99d76f256ab22f52025-08-20T02:32:56ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-05-011710.3389/fnagi.2025.15580781558078Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathwaysJihe Kang0Mei Liu1Qiang Yang2Xiangji Dang3Qun Li4Ting Wang5Bin Qiu6Yibao Zhang7Xudong Guo8Xiaoling Li9Yan Liu10Department of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Pharmaceutical, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaUltrasound Medical Center, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Rehabilitation Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou, ChinaAlzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive dysfunction that affects millions of people worldwide, placing a massive burden on families and economies. Exercise training can effectively reduce the prevalence of AD and alleviate its symptoms through the modulation of multiple signaling pathways involved in the pathophysiological process of AD, including the PI3K/Akt, Wnt/β-catenin, AMPK-related, MAPK, NF-κB, PINK1-PARKIN, JAK/STAT, and TREM2 signaling pathways. Different signaling pathways also crosstalk with each other through different targets to inhibit the formation of Amyloid β (Aβ) plaques, reduce the level of hyperphosphorylated tau protein, reduce apoptosis, relieve neuroinflammation, reduce autophagy dysfunction, and ultimately improve cognitive impairment in AD patients. This review summarizes the pathophysiological processes of AD affected by exercise training through different signaling pathways. We further provide a reference for the future development of new effective AD prevention and treatment targets to develop promising personalized, combined intervention strategies.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1558078/fullexercise trainingAlzheimer’s diseasesignaling pathwayAβ metabolismtau pathologyPI3K/Akt signaling pathway |
| spellingShingle | Jihe Kang Mei Liu Qiang Yang Xiangji Dang Qun Li Ting Wang Bin Qiu Yibao Zhang Xudong Guo Xiaoling Li Yan Liu Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways Frontiers in Aging Neuroscience exercise training Alzheimer’s disease signaling pathway Aβ metabolism tau pathology PI3K/Akt signaling pathway |
| title | Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways |
| title_full | Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways |
| title_fullStr | Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways |
| title_full_unstemmed | Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways |
| title_short | Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways |
| title_sort | exercise training exerts beneficial effects on alzheimer s disease through multiple signaling pathways |
| topic | exercise training Alzheimer’s disease signaling pathway Aβ metabolism tau pathology PI3K/Akt signaling pathway |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1558078/full |
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