The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study
Kidney transplant recipients are at higher risk of developing coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the pattern, pharmacotherapy, drug interactions, and clinical outcome of COVID-19 in kidney transplant recipients at a referral center in Iran. This retrospective,...
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Shiraz University of Medical Sciences
2025-03-01
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| Series: | Trends in Pharmaceutical Sciences |
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| Online Access: | https://tips.sums.ac.ir/article_50714_44e3e00eec26a043f1a94704693db1d1.pdf |
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| author | Tannaz Alam-Rahnama Mojtaba Shafiekhani Shokooh Behdadian Iman Karimzadeh |
| author_facet | Tannaz Alam-Rahnama Mojtaba Shafiekhani Shokooh Behdadian Iman Karimzadeh |
| author_sort | Tannaz Alam-Rahnama |
| collection | DOAJ |
| description | Kidney transplant recipients are at higher risk of developing coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the pattern, pharmacotherapy, drug interactions, and clinical outcome of COVID-19 in kidney transplant recipients at a referral center in Iran. This retrospective, observational study was conducted in Abu Ali Sina Organ transplantation center in Shiraz, Iran. All adult kidney transplant patients diagnosed with COVID-19 and hospitalized for at least 48 hours were included. Required data were collected by reviewing medical charts and health information system of patients at hospital. Potential drug-drug interactions were identified using Lexi-Interact online as well as the Liverpool interactions online website. A total of 108 patients were included. Fever, cough, and shortness of breath were the most common clinical symptoms. About three-fourth (74%) of patients had non-severe COVID-19. Remdesivir was the most widely used antiviral agent. mTOR inhibitors and anti-metabolites were either dose reduced or discontinued in 100% and 80.2% of cases, respectively. Age (odds ratio [OR] = 1.06, 95% [Cl] = 1.02-1.09), calcineurin inhibitor adjustment (OR = 0.26, 95% Cl = 0.09-0.75), baseline white blood cell count (OR = 1.13, 95% Cl = 1.01-1.28), baseline serum lactate dehydrogenase level (OR = 1.32, 95% Cl = 1.03-1.69), administration of tocilizumab (OR = 0.06, 95% Cl = 0.07-0.54), and the severity of COVID-19 disease (OR = 0.03, 95% Cl = 0.00-0.03) had significant association with mortality. The present investigation found that COVID-19 infection in kidney transplant patients may be severe and require hospitalization and even, critical care. |
| format | Article |
| id | doaj-art-841137ffb5604cddadab17df407cfeeb |
| institution | OA Journals |
| issn | 2423-5652 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj-art-841137ffb5604cddadab17df407cfeeb2025-08-20T01:49:43ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522025-03-0111111610.30476/tips.2025.105143.127650714The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational studyTannaz Alam-Rahnama0Mojtaba Shafiekhani1Shokooh Behdadian2Iman Karimzadeh3Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Kidney transplant recipients are at higher risk of developing coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the pattern, pharmacotherapy, drug interactions, and clinical outcome of COVID-19 in kidney transplant recipients at a referral center in Iran. This retrospective, observational study was conducted in Abu Ali Sina Organ transplantation center in Shiraz, Iran. All adult kidney transplant patients diagnosed with COVID-19 and hospitalized for at least 48 hours were included. Required data were collected by reviewing medical charts and health information system of patients at hospital. Potential drug-drug interactions were identified using Lexi-Interact online as well as the Liverpool interactions online website. A total of 108 patients were included. Fever, cough, and shortness of breath were the most common clinical symptoms. About three-fourth (74%) of patients had non-severe COVID-19. Remdesivir was the most widely used antiviral agent. mTOR inhibitors and anti-metabolites were either dose reduced or discontinued in 100% and 80.2% of cases, respectively. Age (odds ratio [OR] = 1.06, 95% [Cl] = 1.02-1.09), calcineurin inhibitor adjustment (OR = 0.26, 95% Cl = 0.09-0.75), baseline white blood cell count (OR = 1.13, 95% Cl = 1.01-1.28), baseline serum lactate dehydrogenase level (OR = 1.32, 95% Cl = 1.03-1.69), administration of tocilizumab (OR = 0.06, 95% Cl = 0.07-0.54), and the severity of COVID-19 disease (OR = 0.03, 95% Cl = 0.00-0.03) had significant association with mortality. The present investigation found that COVID-19 infection in kidney transplant patients may be severe and require hospitalization and even, critical care.https://tips.sums.ac.ir/article_50714_44e3e00eec26a043f1a94704693db1d1.pdfkidney transplantationcovid 19pharmacotherapydrug interactions |
| spellingShingle | Tannaz Alam-Rahnama Mojtaba Shafiekhani Shokooh Behdadian Iman Karimzadeh The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study Trends in Pharmaceutical Sciences kidney transplantation covid 19 pharmacotherapy drug interactions |
| title | The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study |
| title_full | The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study |
| title_fullStr | The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study |
| title_full_unstemmed | The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study |
| title_short | The pattern, pharmacotherapy course, drug-drug interactions, and clinical outcome of COVID-19 in kidney transplant patients at a referral transplantation hospital in Iran: A retrospective, observational study |
| title_sort | pattern pharmacotherapy course drug drug interactions and clinical outcome of covid 19 in kidney transplant patients at a referral transplantation hospital in iran a retrospective observational study |
| topic | kidney transplantation covid 19 pharmacotherapy drug interactions |
| url | https://tips.sums.ac.ir/article_50714_44e3e00eec26a043f1a94704693db1d1.pdf |
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