Role of matrix metalloproteinase 7 in ovarian cancer (review of literature)
Ovarian carcinoma is one of the most aggressive cancer in women, and one of the leading causes of death from cancer of the reproductive system. Despite enhancement methods of prevention, early diagnosis, treatment, such as surgery, radiation, drugs, including targeted and hormone therapy, long-term...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-09-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/449 |
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| author | R. I. Knyazev I. I. Bokin V. V. Barinov |
| author_facet | R. I. Knyazev I. I. Bokin V. V. Barinov |
| author_sort | R. I. Knyazev |
| collection | DOAJ |
| description | Ovarian carcinoma is one of the most aggressive cancer in women, and one of the leading causes of death from cancer of the reproductive system. Despite enhancement methods of prevention, early diagnosis, treatment, such as surgery, radiation, drugs, including targeted and hormone therapy, long-term results remain unsatisfactory. In this connection, much attention is paid to the search for molecular biological mechanisms involved in carcinogenesis and the development of laboratory tests for detecting patients at early stages of tumor process, to differentiate malignant and benign tumors, to determine the tactics of treatment of a particular patient, to assess the prognosis. One of the key aspects of the pathogenesis of ovarian cancer is the interaction of tumor tissue extracellular matrix, the protein degradation of which in most cases is controlled by proteolytic enzymes. Matrix metalloproteinase 7 (MMP-7), also known as matrilysin, like other members of the matrix metalloproteinase` family, demonstrates proteolytic activity against components of the extracellular matrix, the degradation of which is the basis of cancer invasion and metastasis. Matrilysin is also involved in the regulation of activities of bioactive molecules associated with cell physiology. The overview briefly highlights the role of MMP-7 in ovarian cancer. |
| format | Article |
| id | doaj-art-840936dca3994f87bc0e6510098629ae |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-840936dca3994f87bc0e6510098629ae2025-08-20T04:00:01ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272015-09-01113677110.17650/1994-4098-2015-11-3-67-71462Role of matrix metalloproteinase 7 in ovarian cancer (review of literature)R. I. Knyazev0I. I. Bokin1V. V. Barinov2Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia; 2/1 Barrikadnaya St., Moscow, 123995, RussiaRussian Medical Academy of Postgraduate Education, Ministry of Health of Russia; 2/1 Barrikadnaya St., Moscow, 123995, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaOvarian carcinoma is one of the most aggressive cancer in women, and one of the leading causes of death from cancer of the reproductive system. Despite enhancement methods of prevention, early diagnosis, treatment, such as surgery, radiation, drugs, including targeted and hormone therapy, long-term results remain unsatisfactory. In this connection, much attention is paid to the search for molecular biological mechanisms involved in carcinogenesis and the development of laboratory tests for detecting patients at early stages of tumor process, to differentiate malignant and benign tumors, to determine the tactics of treatment of a particular patient, to assess the prognosis. One of the key aspects of the pathogenesis of ovarian cancer is the interaction of tumor tissue extracellular matrix, the protein degradation of which in most cases is controlled by proteolytic enzymes. Matrix metalloproteinase 7 (MMP-7), also known as matrilysin, like other members of the matrix metalloproteinase` family, demonstrates proteolytic activity against components of the extracellular matrix, the degradation of which is the basis of cancer invasion and metastasis. Matrilysin is also involved in the regulation of activities of bioactive molecules associated with cell physiology. The overview briefly highlights the role of MMP-7 in ovarian cancer.https://ojrs.abvpress.ru/ojrs/article/view/449ovarian cancercarcinogenesisinvasionmetastasisextracellular matrixenzymematrix metalloproteinasematrilysindiag- nosticsprognosis |
| spellingShingle | R. I. Knyazev I. I. Bokin V. V. Barinov Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) Опухоли женской репродуктивной системы ovarian cancer carcinogenesis invasion metastasis extracellular matrix enzyme matrix metalloproteinase matrilysin diag- nostics prognosis |
| title | Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) |
| title_full | Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) |
| title_fullStr | Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) |
| title_full_unstemmed | Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) |
| title_short | Role of matrix metalloproteinase 7 in ovarian cancer (review of literature) |
| title_sort | role of matrix metalloproteinase 7 in ovarian cancer review of literature |
| topic | ovarian cancer carcinogenesis invasion metastasis extracellular matrix enzyme matrix metalloproteinase matrilysin diag- nostics prognosis |
| url | https://ojrs.abvpress.ru/ojrs/article/view/449 |
| work_keys_str_mv | AT riknyazev roleofmatrixmetalloproteinase7inovariancancerreviewofliterature AT iibokin roleofmatrixmetalloproteinase7inovariancancerreviewofliterature AT vvbarinov roleofmatrixmetalloproteinase7inovariancancerreviewofliterature |