Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study
Background: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. Thi...
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2024-11-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00150/_html/-char/en |
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| author | Hiroshi Kurosaka Takashi Kimura Jia-Yi Dong Meishan Cui Satoyo Ikehara Kimiko Ueda Hiroyasu Iso Takashi Yamashiro the Japan Environment and Children’s Study Group |
| author_facet | Hiroshi Kurosaka Takashi Kimura Jia-Yi Dong Meishan Cui Satoyo Ikehara Kimiko Ueda Hiroyasu Iso Takashi Yamashiro the Japan Environment and Children’s Study Group |
| author_sort | Hiroshi Kurosaka |
| collection | DOAJ |
| description | Background: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P. Methods: We investigated the association between a history different types of CL/P and the risk of infectious diseases among 1-year old children in the Japan Environment and Children’s Study (JECS). Among the 104,065 registered fetal records, 92,590 eligible participants were included in the analysis. Results: The multivariable-adjusted risk ratios (95% confidence intervals) for otitis media were increased in cleft lip and palate (CLP) and cleft palate only (CPO) groups by 3.81 (2.73–5.31) and 2.27 (1.22–4.22), respectively. The prevalence of Upper respiratory inflammation (URTI) was not associated with CLP, cleft lip only, or CPO. However, analysis in all groups showed a higher risk of URTI compared with the control group (1.31 [1.04–1.66]). Conclusions: CL/P care requires additional attention to prevent airway infectious diseases such as URTI before 1 year of age. Further research is warranted to elucidate the relationship between CL/P and general medical conditions. |
| format | Article |
| id | doaj-art-8406fd3ea5524e8dae7ed61e122e04cb |
| institution | OA Journals |
| issn | 1342-078X 1347-4715 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj-art-8406fd3ea5524e8dae7ed61e122e04cb2025-08-20T02:28:26ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152024-11-0129666610.1265/ehpm.24-00150ehpmHigher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s StudyHiroshi Kurosaka0https://orcid.org/0000-0002-8956-5467Takashi Kimura1Jia-Yi Dong2Meishan Cui3Satoyo Ikehara4Kimiko Ueda5Hiroyasu Iso6Takashi Yamashiro7the Japan Environment and Children’s Study GroupDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka UniversityDepartment of Public Health, Hokkaido University Graduate School of MedicinePublic Health, Department of Social Medicine, Osaka University Graduate School of MedicinePublic Health, Department of Social Medicine, Osaka University Graduate School of MedicinePublic Health, Department of Social Medicine, Osaka University Graduate School of MedicineOsaka Maternal and Child Health Information Center, Osaka Women’s and Children’s HospitalPublic Health, Department of Social Medicine, Osaka University Graduate School of MedicineDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka UniversityBackground: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P. Methods: We investigated the association between a history different types of CL/P and the risk of infectious diseases among 1-year old children in the Japan Environment and Children’s Study (JECS). Among the 104,065 registered fetal records, 92,590 eligible participants were included in the analysis. Results: The multivariable-adjusted risk ratios (95% confidence intervals) for otitis media were increased in cleft lip and palate (CLP) and cleft palate only (CPO) groups by 3.81 (2.73–5.31) and 2.27 (1.22–4.22), respectively. The prevalence of Upper respiratory inflammation (URTI) was not associated with CLP, cleft lip only, or CPO. However, analysis in all groups showed a higher risk of URTI compared with the control group (1.31 [1.04–1.66]). Conclusions: CL/P care requires additional attention to prevent airway infectious diseases such as URTI before 1 year of age. Further research is warranted to elucidate the relationship between CL/P and general medical conditions.https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00150/_html/-char/encleft lip and/or palateupper respiratory inflammationotitis medialarge cohort |
| spellingShingle | Hiroshi Kurosaka Takashi Kimura Jia-Yi Dong Meishan Cui Satoyo Ikehara Kimiko Ueda Hiroyasu Iso Takashi Yamashiro the Japan Environment and Children’s Study Group Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study Environmental Health and Preventive Medicine cleft lip and/or palate upper respiratory inflammation otitis media large cohort |
| title | Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study |
| title_full | Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study |
| title_fullStr | Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study |
| title_full_unstemmed | Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study |
| title_short | Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study |
| title_sort | higher risk of respiratory infections and otitis media in cleft lip and or palate patients the japan environment and children s study |
| topic | cleft lip and/or palate upper respiratory inflammation otitis media large cohort |
| url | https://www.jstage.jst.go.jp/article/ehpm/29/0/29_24-00150/_html/-char/en |
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