Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound
Acoustic droplet vaporization (ADV) plays a crucial role in ultrasound-related biomedical applications. While previous models have examined the stages of nucleation, growth, and oscillation in isolation, which may limit their ability to fully describe the entire ADV process. To address this, our stu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000136 |
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| author | Yubo Zhao Yi Feng Liang Wu |
| author_facet | Yubo Zhao Yi Feng Liang Wu |
| author_sort | Yubo Zhao |
| collection | DOAJ |
| description | Acoustic droplet vaporization (ADV) plays a crucial role in ultrasound-related biomedical applications. While previous models have examined the stages of nucleation, growth, and oscillation in isolation, which may limit their ability to fully describe the entire ADV process. To address this, our study developed an integrated model that unifies these three stages of ADV, stimulated by a continuous nonlinear dual-frequency ultrasound wave. Using this integrated model, we investigated the influence of nonlinear dual-frequency ultrasound parameters on ADV dynamics and bioeffects by incorporating tissue viscoelasticity through parametric studies. Our results demonstrated that the proposed model accurately captured the entire ADV process, ensuring continuous vapor bubble formation and evolution throughout the phase transition process. Moreover, the applied unified theory for bubble dynamics can simulate intense bubble collapse with high Mach Number as a result of the nonlinear effects of dual-frequency ultrasound. In addition, cavitation-associated mechanical and thermal damage appeared to be more strongly correlated with rapid bubble collapse than with maximum bubble size. Our research also revealed that the mechanical and thermal effects could be regulated independently to some extent by adjusting dual-frequency ultrasound parameters, as they presented differing sensitivities to frequency and acoustic power. Importantly, dual-frequency combinations such as 1.5 MHz + 3 MHz (fundamental and second harmonic), which exhibit a higher Degree of Nonlinearity (DoN) can extend bubble lifespan, offering a potential pathway to the efficacy of ultrasound treatments. |
| format | Article |
| id | doaj-art-8406f4b94b21458a8cacb3b9670c2023 |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-8406f4b94b21458a8cacb3b9670c20232025-02-01T04:11:38ZengElsevierUltrasonics Sonochemistry1350-41772025-02-01113107234Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasoundYubo Zhao0Yi Feng1Liang Wu2The Key Laboratory of Biomedical Information Engineering of Ministry of Education Department of Biomedical Engineering School of Life Science and Technology Xi’an Jiaotong University Xi’an People's Republic of ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Department of Biomedical Engineering School of Life Science and Technology Xi’an Jiaotong University Xi’an People's Republic of ChinaCorresponding author.; The Key Laboratory of Biomedical Information Engineering of Ministry of Education Department of Biomedical Engineering School of Life Science and Technology Xi’an Jiaotong University Xi’an People's Republic of ChinaAcoustic droplet vaporization (ADV) plays a crucial role in ultrasound-related biomedical applications. While previous models have examined the stages of nucleation, growth, and oscillation in isolation, which may limit their ability to fully describe the entire ADV process. To address this, our study developed an integrated model that unifies these three stages of ADV, stimulated by a continuous nonlinear dual-frequency ultrasound wave. Using this integrated model, we investigated the influence of nonlinear dual-frequency ultrasound parameters on ADV dynamics and bioeffects by incorporating tissue viscoelasticity through parametric studies. Our results demonstrated that the proposed model accurately captured the entire ADV process, ensuring continuous vapor bubble formation and evolution throughout the phase transition process. Moreover, the applied unified theory for bubble dynamics can simulate intense bubble collapse with high Mach Number as a result of the nonlinear effects of dual-frequency ultrasound. In addition, cavitation-associated mechanical and thermal damage appeared to be more strongly correlated with rapid bubble collapse than with maximum bubble size. Our research also revealed that the mechanical and thermal effects could be regulated independently to some extent by adjusting dual-frequency ultrasound parameters, as they presented differing sensitivities to frequency and acoustic power. Importantly, dual-frequency combinations such as 1.5 MHz + 3 MHz (fundamental and second harmonic), which exhibit a higher Degree of Nonlinearity (DoN) can extend bubble lifespan, offering a potential pathway to the efficacy of ultrasound treatments.http://www.sciencedirect.com/science/article/pii/S1350417725000136Dual-frequency focused ultrasoundWhole-process vaporization dynamicsUltrasound bioeffectsViscoelastic tissueOn-demand regulation |
| spellingShingle | Yubo Zhao Yi Feng Liang Wu Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound Ultrasonics Sonochemistry Dual-frequency focused ultrasound Whole-process vaporization dynamics Ultrasound bioeffects Viscoelastic tissue On-demand regulation |
| title | Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound |
| title_full | Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound |
| title_fullStr | Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound |
| title_full_unstemmed | Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound |
| title_short | Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound |
| title_sort | process dynamics and bioeffects of acoustic droplet vaporization induced by dual frequency focused ultrasound |
| topic | Dual-frequency focused ultrasound Whole-process vaporization dynamics Ultrasound bioeffects Viscoelastic tissue On-demand regulation |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000136 |
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