Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol
Commercially available, crude pig liver material (Pig Liver Acetone Powder, PLAP) is demonstrated to be effective for the preparation of enantiomerically pure alcohols that are, in turn, effective chiral auxiliaries for asymmetric induction. Resolution of the title alcohols in large scale is effect...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1986-09-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9750 |
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| _version_ | 1850283747548594176 |
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| author | James K. Whitesell Robert M. Lawrence |
| author_facet | James K. Whitesell Robert M. Lawrence |
| author_sort | James K. Whitesell |
| collection | DOAJ |
| description |
Commercially available, crude pig liver material (Pig Liver Acetone Powder, PLAP) is demonstrated to be effective for the preparation of enantiomerically pure alcohols that are, in turn, effective chiral auxiliaries for asymmetric induction. Resolution of the title alcohols in large scale is effected by selective enzymatic cleavage of the corresponding acetic acid esters.
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| format | Article |
| id | doaj-art-83ff6ebe314542f9872eec3811effeab |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1986-09-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-83ff6ebe314542f9872eec3811effeab2025-08-20T01:47:43ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241986-09-0140910.2533/chimia.1986.318Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanolJames K. Whitesell0Robert M. Lawrence1Department of Chemistry The University of Texas at Austin Austin, TX 78712 (USA)Department of Chemistry The University of Texas at Austin Austin, TX 78712 (USA) Commercially available, crude pig liver material (Pig Liver Acetone Powder, PLAP) is demonstrated to be effective for the preparation of enantiomerically pure alcohols that are, in turn, effective chiral auxiliaries for asymmetric induction. Resolution of the title alcohols in large scale is effected by selective enzymatic cleavage of the corresponding acetic acid esters. https://www.chimia.ch/chimia/article/view/9750 |
| spellingShingle | James K. Whitesell Robert M. Lawrence Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol CHIMIA |
| title | Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol |
| title_full | Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol |
| title_fullStr | Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol |
| title_full_unstemmed | Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol |
| title_short | Practical Enzymatic Resolution of Chiral Auxiliaries – Enantiomerically Pure trans-2-Phenylcyclohexanol and trans-2-(α-Cumyl)cyclohexanol |
| title_sort | practical enzymatic resolution of chiral auxiliaries enantiomerically pure trans 2 phenylcyclohexanol and trans 2 α cumyl cyclohexanol |
| url | https://www.chimia.ch/chimia/article/view/9750 |
| work_keys_str_mv | AT jameskwhitesell practicalenzymaticresolutionofchiralauxiliariesenantiomericallypuretrans2phenylcyclohexanolandtrans2acumylcyclohexanol AT robertmlawrence practicalenzymaticresolutionofchiralauxiliariesenantiomericallypuretrans2phenylcyclohexanolandtrans2acumylcyclohexanol |