Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England
Objectives The validity of bullous pemphigoid and pemphigus vulgaris recording in routinely collected healthcare data in the UK is unknown. We assessed the positive predictive value (PPV) for bullous pemphigoid and pemphigus vulgaris primary care Read codes in the Clinical Practice Research Datalink...
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BMJ Publishing Group
2020-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/7/e035934.full |
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| author | Yana Vinogradova Julia Hippisley-Cox Sonia Gran Sinéad M Langan Monica S M Persson Karen E Harman Kim S Thomas |
| author_facet | Yana Vinogradova Julia Hippisley-Cox Sonia Gran Sinéad M Langan Monica S M Persson Karen E Harman Kim S Thomas |
| author_sort | Yana Vinogradova |
| collection | DOAJ |
| description | Objectives The validity of bullous pemphigoid and pemphigus vulgaris recording in routinely collected healthcare data in the UK is unknown. We assessed the positive predictive value (PPV) for bullous pemphigoid and pemphigus vulgaris primary care Read codes in the Clinical Practice Research Datalink (CPRD) using linked inpatient data (Hospital Episode Statistics (HES)) as the diagnostic benchmark.Setting Adult participants with bullous pemphigoid or pemphigus vulgaris registered with HES-linked general practices in England between January 1998 and December 2017. Code-based algorithms were used to identify patients from the CPRD and extract their benchmark blistering disease diagnosis from HES.Primary outcome measure The PPVs of Read codes for bullous pemphigoid and pemphigus vulgaris.Results Of 2468 incident cases of bullous pemphigoid and 431 of pemphigus vulgaris, 797 (32.3%) and 85 (19.7%) patients, respectively, had a hospitalisation record for a blistering disease. The PPV for bullous pemphigoid Read codes was 93.2% (95% CI 91.3% to 94.8%). Of the bullous pemphigoid cases, 3.0% had an HES diagnosis of pemphigus vulgaris and 3.8% of another blistering disease. The PPV for pemphigus vulgaris Read codes was 58.5% (95% CI 48.0% to 68.9%). Of the pemphigus vulgaris cases, 24.7% had an HES diagnosis of bullous pemphigoid and 16.5% of another blistering disease.Conclusions The CPRD can be used to study bullous pemphigoid, but recording of pemphigus vulgaris needs to improve in primary care. |
| format | Article |
| id | doaj-art-83f52502668c4ae997cbab1cccb72b64 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-83f52502668c4ae997cbab1cccb72b642025-08-20T02:19:30ZengBMJ Publishing GroupBMJ Open2044-60552020-07-0110710.1136/bmjopen-2019-035934Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in EnglandYana Vinogradova0Julia Hippisley-Cox1Sonia Gran2Sinéad M Langan3Monica S M Persson4Karen E Harman5Kim S Thomas6University of Nottingham, UK10 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK1 Centre of Evidence Based Dermatology, School of Medicine, University of Nottingham, Nottingham, UKDepartment of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenCentre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK5 Centre for Evidence Based Dermatology, University of Nottingham, Nottingham, UKObjectives The validity of bullous pemphigoid and pemphigus vulgaris recording in routinely collected healthcare data in the UK is unknown. We assessed the positive predictive value (PPV) for bullous pemphigoid and pemphigus vulgaris primary care Read codes in the Clinical Practice Research Datalink (CPRD) using linked inpatient data (Hospital Episode Statistics (HES)) as the diagnostic benchmark.Setting Adult participants with bullous pemphigoid or pemphigus vulgaris registered with HES-linked general practices in England between January 1998 and December 2017. Code-based algorithms were used to identify patients from the CPRD and extract their benchmark blistering disease diagnosis from HES.Primary outcome measure The PPVs of Read codes for bullous pemphigoid and pemphigus vulgaris.Results Of 2468 incident cases of bullous pemphigoid and 431 of pemphigus vulgaris, 797 (32.3%) and 85 (19.7%) patients, respectively, had a hospitalisation record for a blistering disease. The PPV for bullous pemphigoid Read codes was 93.2% (95% CI 91.3% to 94.8%). Of the bullous pemphigoid cases, 3.0% had an HES diagnosis of pemphigus vulgaris and 3.8% of another blistering disease. The PPV for pemphigus vulgaris Read codes was 58.5% (95% CI 48.0% to 68.9%). Of the pemphigus vulgaris cases, 24.7% had an HES diagnosis of bullous pemphigoid and 16.5% of another blistering disease.Conclusions The CPRD can be used to study bullous pemphigoid, but recording of pemphigus vulgaris needs to improve in primary care.https://bmjopen.bmj.com/content/10/7/e035934.full |
| spellingShingle | Yana Vinogradova Julia Hippisley-Cox Sonia Gran Sinéad M Langan Monica S M Persson Karen E Harman Kim S Thomas Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England BMJ Open |
| title | Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England |
| title_full | Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England |
| title_fullStr | Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England |
| title_full_unstemmed | Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England |
| title_short | Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England |
| title_sort | validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in england |
| url | https://bmjopen.bmj.com/content/10/7/e035934.full |
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