Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy
The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. Boron-dipyrromethene (BODIPY)derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and v...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/14/1/71 |
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| author | Raquel C. R. Gonçalves Sónia C. S. Pinto João Pina Lígia C. Gomes-da-Silva Susana P. G. Costa M. Manuela M. Raposo |
| author_facet | Raquel C. R. Gonçalves Sónia C. S. Pinto João Pina Lígia C. Gomes-da-Silva Susana P. G. Costa M. Manuela M. Raposo |
| author_sort | Raquel C. R. Gonçalves |
| collection | DOAJ |
| description | The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. Boron-dipyrromethene (BODIPY)derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues <i>meso</i>-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at the 2,6-position. The formylated anthracene–BODIPY derivative exhibited the highest phototoxicity in 4T1 breast cancer cells, making it a potential candidate for a PDT photosensitizer. |
| format | Article |
| id | doaj-art-83f475e4f9d34a7aa4db0778d92063cf |
| institution | DOAJ |
| issn | 2673-4583 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj-art-83f475e4f9d34a7aa4db0778d92063cf2025-08-20T02:53:40ZengMDPI AGChemistry Proceedings2673-45832023-11-011417110.3390/ecsoc-27-16094Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic TherapyRaquel C. R. Gonçalves0Sónia C. S. Pinto1João Pina2Lígia C. Gomes-da-Silva3Susana P. G. Costa4M. Manuela M. Raposo5Centre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalDepartment of Chemistry, Coimbra Chemistry Centre, University of Coimbra, Rua Larga, 3004-535 Coimbra, PortugalDepartment of Chemistry, Coimbra Chemistry Centre, University of Coimbra, Rua Larga, 3004-535 Coimbra, PortugalCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalCentre of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalThe selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. Boron-dipyrromethene (BODIPY)derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues <i>meso</i>-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at the 2,6-position. The formylated anthracene–BODIPY derivative exhibited the highest phototoxicity in 4T1 breast cancer cells, making it a potential candidate for a PDT photosensitizer.https://www.mdpi.com/2673-4583/14/1/71BODIPY derivativecancer therapyphotosensitizersphotodynamic therapysinglet oxygen quantum yield |
| spellingShingle | Raquel C. R. Gonçalves Sónia C. S. Pinto João Pina Lígia C. Gomes-da-Silva Susana P. G. Costa M. Manuela M. Raposo Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy Chemistry Proceedings BODIPY derivative cancer therapy photosensitizers photodynamic therapy singlet oxygen quantum yield |
| title | Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy |
| title_full | Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy |
| title_fullStr | Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy |
| title_full_unstemmed | Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy |
| title_short | Investigating the Photophysical Properties and Biological Efficacy of BODIPY Derivatives as Photosensitizers in Photodynamic Therapy |
| title_sort | investigating the photophysical properties and biological efficacy of bodipy derivatives as photosensitizers in photodynamic therapy |
| topic | BODIPY derivative cancer therapy photosensitizers photodynamic therapy singlet oxygen quantum yield |
| url | https://www.mdpi.com/2673-4583/14/1/71 |
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