Idiopathic multicentric Castleman disease: A case report
Castleman disease is a rare disease affecting lymph nodes and is considered a non-clonal lymphoproliferative disorder. It has variable clinical presentation and is divided into clinical and histopathological subtypes. Careful evaluation of history and blood investigations contributes to the diagnosi...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2025-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4623 |
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| author | Anna John Sheima R Das |
| author_facet | Anna John Sheima R Das |
| author_sort | Anna John |
| collection | DOAJ |
| description | Castleman disease is a rare disease affecting lymph nodes and is considered a non-clonal lymphoproliferative disorder. It has variable clinical presentation and is divided into clinical and histopathological subtypes. Careful evaluation of history and blood investigations contributes to the diagnosis but histopathology remains the precise modality. Treatment involves excision of the affected lymph node in unicentric type of Castleman disease whereas monoclonal antibodies and steroids remain the mainstay of treatment in multicentric Castleman disease. We are presenting a case of 41-year-old female who was on treatment for deep vein thrombosis, presented with generalized lymphadenopathy, investigated for immunoglobulin G4 related disease and lymphoma which was finally proved as idiopathic multicentric Castleman disease. |
| format | Article |
| id | doaj-art-83f467b0d0c64c35ab7e0f2cee88c259 |
| institution | DOAJ |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-83f467b0d0c64c35ab7e0f2cee88c2592025-08-20T03:16:28ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-08-01168145147https://doi.org/10.71152/ajms.v16i8.4623Idiopathic multicentric Castleman disease: A case reportAnna John 0https://orcid.org/0009-0005-7704-767XSheima R Das 1https://orcid.org/0009-0004-3018-3503Postgraduate Resident, Department of Pathology, Government Medical College, Kottayam, Kerala, India Professor, Department of Pathology, Government Medical College, Kottayam, Kerala, India Castleman disease is a rare disease affecting lymph nodes and is considered a non-clonal lymphoproliferative disorder. It has variable clinical presentation and is divided into clinical and histopathological subtypes. Careful evaluation of history and blood investigations contributes to the diagnosis but histopathology remains the precise modality. Treatment involves excision of the affected lymph node in unicentric type of Castleman disease whereas monoclonal antibodies and steroids remain the mainstay of treatment in multicentric Castleman disease. We are presenting a case of 41-year-old female who was on treatment for deep vein thrombosis, presented with generalized lymphadenopathy, investigated for immunoglobulin G4 related disease and lymphoma which was finally proved as idiopathic multicentric Castleman disease.https://ajmsjournal.info/index.php/AJMS/article/view/4623multicentric castleman disease; lymphadenopathy; lymphoproliferative disorders; interleukin-6 |
| spellingShingle | Anna John Sheima R Das Idiopathic multicentric Castleman disease: A case report Asian Journal of Medical Sciences multicentric castleman disease; lymphadenopathy; lymphoproliferative disorders; interleukin-6 |
| title | Idiopathic multicentric Castleman disease: A case report |
| title_full | Idiopathic multicentric Castleman disease: A case report |
| title_fullStr | Idiopathic multicentric Castleman disease: A case report |
| title_full_unstemmed | Idiopathic multicentric Castleman disease: A case report |
| title_short | Idiopathic multicentric Castleman disease: A case report |
| title_sort | idiopathic multicentric castleman disease a case report |
| topic | multicentric castleman disease; lymphadenopathy; lymphoproliferative disorders; interleukin-6 |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4623 |
| work_keys_str_mv | AT annajohn idiopathicmulticentriccastlemandiseaseacasereport AT sheimardas idiopathicmulticentriccastlemandiseaseacasereport |