Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF

Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF

Connective tissue growth factor (CTGF) is notably upregulated in scar tissue, making it a promising target for therapeutic intervention. Here, we have designed and screened an antisense oligonucleotide (ASO) that binds specifically to the exon five sequence of CTGF, with particular emphasis on the u...

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Bibliographic Details
Main Authors: Jinhe Li, Xi Wu, Ying Yang, Ruiqi Mao, Zherui Li, Xiujun Zhang, Wenguo Wei, Wendi Wang, Hailong Li, Honggang Zhou, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
CTGF
antisense oligonucleotide
scar
LNA
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1623640/full
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