Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials
The diagnosis of brain tumors typically relies on magnetic resonance imaging (MRI), computed tomography (CT), and invasive procedures like biopsies or surgical resection for confirmation and genetic profiling. However, these methods have limitations, especially in distinguishing treatment effects li...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | The Journal of Liquid Biopsy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195424001437 |
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| author | Muhammad Izhar Abhimanyu Thakur David J. Park Steven D. Chang |
| author_facet | Muhammad Izhar Abhimanyu Thakur David J. Park Steven D. Chang |
| author_sort | Muhammad Izhar |
| collection | DOAJ |
| description | The diagnosis of brain tumors typically relies on magnetic resonance imaging (MRI), computed tomography (CT), and invasive procedures like biopsies or surgical resection for confirmation and genetic profiling. However, these methods have limitations, especially in distinguishing treatment effects like pseudo-progression from actual tumor progression, and repeated biopsies pose risks. Liquid biopsy (LB) offers a non-invasive alternative, detecting tumor-derived biomarkers in blood and cerebrospinal fluid (CSF). Despite its potential, the low concentration of brain tumor biomarkers in blood due to the blood-brain barrier (BBB), limits the clinical utility of LB. MRI-guided focused ultrasound (MRgFUS) combined with microbubbles provides a novel solution by temporarily disrupting the BBB, facilitating the passage of therapeutic agents, and enabling tumor biomarker detection. This technique, termed “sonobiopsy,” enables non-invasive biomarker collection for liquid biopsy, potentially improving brain tumor diagnosis and monitoring. |
| format | Article |
| id | doaj-art-83f09797a52946e8bacf1cd802829da4 |
| institution | OA Journals |
| issn | 2950-1954 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-83f09797a52946e8bacf1cd802829da42025-08-20T02:34:38ZengElsevierThe Journal of Liquid Biopsy2950-19542024-12-01610027710.1016/j.jlb.2024.100277Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trialsMuhammad Izhar0Abhimanyu Thakur1David J. Park2Steven D. Chang3Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USADepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Corresponding author. Department of Neurosurgery, Stanford University School of Medicine, 453 Quarry Rd, Palo Alto, CA, 94304, USA.Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USAThe diagnosis of brain tumors typically relies on magnetic resonance imaging (MRI), computed tomography (CT), and invasive procedures like biopsies or surgical resection for confirmation and genetic profiling. However, these methods have limitations, especially in distinguishing treatment effects like pseudo-progression from actual tumor progression, and repeated biopsies pose risks. Liquid biopsy (LB) offers a non-invasive alternative, detecting tumor-derived biomarkers in blood and cerebrospinal fluid (CSF). Despite its potential, the low concentration of brain tumor biomarkers in blood due to the blood-brain barrier (BBB), limits the clinical utility of LB. MRI-guided focused ultrasound (MRgFUS) combined with microbubbles provides a novel solution by temporarily disrupting the BBB, facilitating the passage of therapeutic agents, and enabling tumor biomarker detection. This technique, termed “sonobiopsy,” enables non-invasive biomarker collection for liquid biopsy, potentially improving brain tumor diagnosis and monitoring.http://www.sciencedirect.com/science/article/pii/S2950195424001437SonobiopsyLiquid biopsyFocused ultrasoundFUS-Mediated liquid biopsyMicrobubblesBBB opening |
| spellingShingle | Muhammad Izhar Abhimanyu Thakur David J. Park Steven D. Chang Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials The Journal of Liquid Biopsy Sonobiopsy Liquid biopsy Focused ultrasound FUS-Mediated liquid biopsy Microbubbles BBB opening |
| title | Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials |
| title_full | Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials |
| title_fullStr | Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials |
| title_full_unstemmed | Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials |
| title_short | Ultrasound mediated blood-brain barrier opening increases brain tumor biomarkers: A review of preclinical and clinical trials |
| title_sort | ultrasound mediated blood brain barrier opening increases brain tumor biomarkers a review of preclinical and clinical trials |
| topic | Sonobiopsy Liquid biopsy Focused ultrasound FUS-Mediated liquid biopsy Microbubbles BBB opening |
| url | http://www.sciencedirect.com/science/article/pii/S2950195424001437 |
| work_keys_str_mv | AT muhammadizhar ultrasoundmediatedbloodbrainbarrieropeningincreasesbraintumorbiomarkersareviewofpreclinicalandclinicaltrials AT abhimanyuthakur ultrasoundmediatedbloodbrainbarrieropeningincreasesbraintumorbiomarkersareviewofpreclinicalandclinicaltrials AT davidjpark ultrasoundmediatedbloodbrainbarrieropeningincreasesbraintumorbiomarkersareviewofpreclinicalandclinicaltrials AT stevendchang ultrasoundmediatedbloodbrainbarrieropeningincreasesbraintumorbiomarkersareviewofpreclinicalandclinicaltrials |