The myriad roles of RNA structure in the flavivirus life cycle
As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2357857 |
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| author | Quinn H. Abram Breanna N. Landry Alex B. Wang Ronja F. Kothe Hannah C.H. Hauch Selena M. Sagan |
| author_facet | Quinn H. Abram Breanna N. Landry Alex B. Wang Ronja F. Kothe Hannah C.H. Hauch Selena M. Sagan |
| author_sort | Quinn H. Abram |
| collection | DOAJ |
| description | As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps shepherd the viral genome through these stages. Herein, we highlight advances in our understanding of flavivirus RNA structural elements through the lens of their impact on the viral life cycle. We highlight how RNA structures impact translation, the switch from translation to replication, negative- and positive-strand RNA synthesis, and virion assembly. Consequently, we describe three major themes regarding the roles of RNA structure in flavivirus infections: 1) providing a layer of specificity; 2) increasing the functional capacity; and 3) providing a mechanism to support genome compaction. While the interactions described herein are specific to flaviviruses, these themes appear to extend more broadly across RNA viruses. |
| format | Article |
| id | doaj-art-83efb38e3a03435ab9d68df284942b57 |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-83efb38e3a03435ab9d68df284942b572025-08-20T01:54:54ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121163465010.1080/15476286.2024.2357857The myriad roles of RNA structure in the flavivirus life cycleQuinn H. Abram0Breanna N. Landry1Alex B. Wang2Ronja F. Kothe3Hannah C.H. Hauch4Selena M. Sagan5Department of Biochemistry, McGill University, Montreal, QC, CanadaDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC, CanadaDepartment of Biochemistry, McGill University, Montreal, QC, CanadaDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC, CanadaDepartment of Microbiology & Immunology, McGill University, Montreal, QC, CanadaDepartment of Biochemistry, McGill University, Montreal, QC, CanadaAs positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps shepherd the viral genome through these stages. Herein, we highlight advances in our understanding of flavivirus RNA structural elements through the lens of their impact on the viral life cycle. We highlight how RNA structures impact translation, the switch from translation to replication, negative- and positive-strand RNA synthesis, and virion assembly. Consequently, we describe three major themes regarding the roles of RNA structure in flavivirus infections: 1) providing a layer of specificity; 2) increasing the functional capacity; and 3) providing a mechanism to support genome compaction. While the interactions described herein are specific to flaviviruses, these themes appear to extend more broadly across RNA viruses.https://www.tandfonline.com/doi/10.1080/15476286.2024.2357857FlavivirusZika virusdengue virustranslationreplicationpackaging |
| spellingShingle | Quinn H. Abram Breanna N. Landry Alex B. Wang Ronja F. Kothe Hannah C.H. Hauch Selena M. Sagan The myriad roles of RNA structure in the flavivirus life cycle RNA Biology Flavivirus Zika virus dengue virus translation replication packaging |
| title | The myriad roles of RNA structure in the flavivirus life cycle |
| title_full | The myriad roles of RNA structure in the flavivirus life cycle |
| title_fullStr | The myriad roles of RNA structure in the flavivirus life cycle |
| title_full_unstemmed | The myriad roles of RNA structure in the flavivirus life cycle |
| title_short | The myriad roles of RNA structure in the flavivirus life cycle |
| title_sort | myriad roles of rna structure in the flavivirus life cycle |
| topic | Flavivirus Zika virus dengue virus translation replication packaging |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2357857 |
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