Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018
IntroductionCardiovascular Disease (CVD) has become a significant global public health challenge, contributing to rising mortality rates. This study aims to investigate the relationship between Life’s Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP), providing insights into the assessment...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1506884/full |
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| author | Long-Hui Xu Kai-Wen Ding Guo-Dong Yang Xiao-Xuan Han Xiao Cong Rong-Hui Wang Xin-Ru Liu Na Li Cui-Ping Xu |
| author_facet | Long-Hui Xu Kai-Wen Ding Guo-Dong Yang Xiao-Xuan Han Xiao Cong Rong-Hui Wang Xin-Ru Liu Na Li Cui-Ping Xu |
| author_sort | Long-Hui Xu |
| collection | DOAJ |
| description | IntroductionCardiovascular Disease (CVD) has become a significant global public health challenge, contributing to rising mortality rates. This study aims to investigate the relationship between Life’s Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP), providing insights into the assessment and improvement of Cardiovascular Health (CVH).MethodsWe conducted an analysis of data from 8,215 U.S. adults aged 20 years and older, utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. Based on the LE8 score, CVH was classified into three levels—low, moderate, and high—while AIP was classified into four risk levels: extremely low (AIP<-0.3), low (-0.3≤AIP<0.1), medium (0.1≤AIP<0.24), and high (AIP≥0.24). Weighted ordinal logistic regression analysis was utilized to examine the association between the LE8 score and the AIP risk level, adjusting for potential confounding variables.ResultsA significant negative correlation exists between the LE8 score and the AIP risk level (OR=0.51, 95%CI: 0.49-0.54, P<0.001). Higher CVH were associated with lower AIP risk levels, while lower CVH corresponded to elevated AIP risk levels. Notably, improvements in specific LE8 components—such as body mass index and blood lipids—exhibited a strong relationship with reductions in the AIP risk level.DiscussionThis study suggests that the LE8 may serve as a preventive factor for CVD risk and implies that individuals can actively regulate their metabolic characteristics by optimizing their lifestyle. |
| format | Article |
| id | doaj-art-83ed1194dbfe4e759174d320f34b8a1c |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-83ed1194dbfe4e759174d320f34b8a1c2025-08-20T03:01:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15068841506884Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018Long-Hui Xu0Kai-Wen Ding1Guo-Dong Yang2Xiao-Xuan Han3Xiao Cong4Rong-Hui Wang5Xin-Ru Liu6Na Li7Cui-Ping Xu8School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaIntroductionCardiovascular Disease (CVD) has become a significant global public health challenge, contributing to rising mortality rates. This study aims to investigate the relationship between Life’s Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP), providing insights into the assessment and improvement of Cardiovascular Health (CVH).MethodsWe conducted an analysis of data from 8,215 U.S. adults aged 20 years and older, utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. Based on the LE8 score, CVH was classified into three levels—low, moderate, and high—while AIP was classified into four risk levels: extremely low (AIP<-0.3), low (-0.3≤AIP<0.1), medium (0.1≤AIP<0.24), and high (AIP≥0.24). Weighted ordinal logistic regression analysis was utilized to examine the association between the LE8 score and the AIP risk level, adjusting for potential confounding variables.ResultsA significant negative correlation exists between the LE8 score and the AIP risk level (OR=0.51, 95%CI: 0.49-0.54, P<0.001). Higher CVH were associated with lower AIP risk levels, while lower CVH corresponded to elevated AIP risk levels. Notably, improvements in specific LE8 components—such as body mass index and blood lipids—exhibited a strong relationship with reductions in the AIP risk level.DiscussionThis study suggests that the LE8 may serve as a preventive factor for CVD risk and implies that individuals can actively regulate their metabolic characteristics by optimizing their lifestyle.https://www.frontiersin.org/articles/10.3389/fendo.2025.1506884/fullLife’s Essential 8Atherogenic Index of Plasmacardiovascular healthcardiovascular diseaseNHANES |
| spellingShingle | Long-Hui Xu Kai-Wen Ding Guo-Dong Yang Xiao-Xuan Han Xiao Cong Rong-Hui Wang Xin-Ru Liu Na Li Cui-Ping Xu Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 Frontiers in Endocrinology Life’s Essential 8 Atherogenic Index of Plasma cardiovascular health cardiovascular disease NHANES |
| title | Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 |
| title_full | Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 |
| title_fullStr | Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 |
| title_full_unstemmed | Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 |
| title_short | Association between Life’s Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007–2018 |
| title_sort | association between life s essential 8 and atherogenic index of plasma in adults insights from nhanes 2007 2018 |
| topic | Life’s Essential 8 Atherogenic Index of Plasma cardiovascular health cardiovascular disease NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1506884/full |
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