Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women
Introduction Multicomponent exercise programs have demonstrated benefits for both cognitive and physical function. However, their effects on brain-derived neurotrophic factor (BDNF) levels remain inconsistent, particularly in protocols incorporating functional exercises. This study aimed to evaluate...
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Medwave Estudios Limitada
2025-05-01
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| Online Access: | https://www.medwave.cl/investigacion/estudios/3010.html |
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| author | Mayara Imaizumi Walter Sepulveda-Loyola Bruna Prado Gomes Camila Pereira Fabiana Cristina Scherer Regina Célia Poli-Frederico Andréa Name Colado Simão Vanessa Suziane Probst Denilson de Castro Teixeira |
| author_facet | Mayara Imaizumi Walter Sepulveda-Loyola Bruna Prado Gomes Camila Pereira Fabiana Cristina Scherer Regina Célia Poli-Frederico Andréa Name Colado Simão Vanessa Suziane Probst Denilson de Castro Teixeira |
| author_sort | Mayara Imaizumi |
| collection | DOAJ |
| description | Introduction Multicomponent exercise programs have demonstrated benefits for both cognitive and physical function. However, their effects on brain-derived neurotrophic factor (BDNF) levels remain inconsistent, particularly in protocols incorporating functional exercises. This study aimed to evaluate the impact of two distinct multicomponent exercise protocols on BDNF levels and physical fitness in older women.
Methods Ninety physically active. community-dwelling older women (70.4 ± 7.2 years) were allocated to three different groups: 1) Multicomponent program 1: Circuit-based functional training; 2) Multicomponent program 2: Pilates Method; and 3) control group that received only health education. Both multicomponent programs were conducted over a 12-week period, with 50-minute sessions held three times per week. The control group participated in 12-week Health Education intervention with 90-minute sessions once a week. Brain-derived neurotrophic factor levels, short physical performance battery, agility, six-minute walk, and handgrip tests were measured.
Results Brain-derived neurotrophic factor levels increased significantly in both the functional training group (p<0.001) and Pilates group (p=0.005), with a more pronounced increase observed in the functional training group. The distance covered in the six-minute walk test also increased significantly in the functional training group (p=0.001) and was greater compared to both the Pilates (p<0.001) and control (p<0.001) groups.
Conclusions Both multicomponent exercise programs led to increased BDNF levels after 12-week intervention. However, functional training yielded superior results compared to the Pilates method, possibly mediated by improvement in physical function. |
| format | Article |
| id | doaj-art-83ecf146a6f944ca991d2b2bbf9dce5a |
| institution | OA Journals |
| issn | 0717-6384 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj-art-83ecf146a6f944ca991d2b2bbf9dce5a2025-08-20T02:32:22ZengMedwave Estudios LimitadaMedwave0717-63842025-05-012504e3010e301010.5867/medwave.2025.04.3010Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older womenMayara Imaizumi0https://orcid.org/0000-0003-4030-1492Walter Sepulveda-Loyola1https://orcid.org/0000-0001-6173-1104Bruna Prado Gomes2https://orcid.org/0000-0002-8424-0399Camila Pereira3https://orcid.org/0000-0002-2179-6293Fabiana Cristina Scherer4https://orcid.org/0000-0001-5051-6193Regina Célia Poli-Frederico5https://orcid.org/0000-0003-4631-4606Andréa Name Colado Simão6https://orcid.org/0000-0002-2073-6782Vanessa Suziane Probst7https://orcid.org/0000-0003-1483-5319Denilson de Castro Teixeira8https://orcid.org/0000-0002-6299-0252 Associate Postgraduate Program in Physical Education, State University of Londrina, Londrina, Paraná, Brazil Faculty of Health and Social Sciences, Universidad de Las Americas, Santiago, Chile Associate Postgraduate Program in Physical Education, State University of Londrina, Londrina, Paraná, Brazil Associate Postgraduate Program in Physical Education, State University of Londrina, Londrina, Paraná, Brazil Associate Postgraduate Program in Physical Education, State University of Londrina, Londrina, Paraná, Brazil Department of Cell and Molecular Biology, University North of Paraná, Londrina, Paraná, Brazil Department of Pathology, Clinical Analysis and Toxicology, Laboratory of Research in Applied Immunology, Health Sciences Center, University Hospital, State University of Londrina, Londrina, Paraná, Brazil Postgraduate Program in Rehabilitation Sciences, State University of Londrina, Londrina, Paraná, Brazil Associate Postgraduate Program in Physical Education, State University of Londrina, Londrina, Paraná, BrazilIntroduction Multicomponent exercise programs have demonstrated benefits for both cognitive and physical function. However, their effects on brain-derived neurotrophic factor (BDNF) levels remain inconsistent, particularly in protocols incorporating functional exercises. This study aimed to evaluate the impact of two distinct multicomponent exercise protocols on BDNF levels and physical fitness in older women. Methods Ninety physically active. community-dwelling older women (70.4 ± 7.2 years) were allocated to three different groups: 1) Multicomponent program 1: Circuit-based functional training; 2) Multicomponent program 2: Pilates Method; and 3) control group that received only health education. Both multicomponent programs were conducted over a 12-week period, with 50-minute sessions held three times per week. The control group participated in 12-week Health Education intervention with 90-minute sessions once a week. Brain-derived neurotrophic factor levels, short physical performance battery, agility, six-minute walk, and handgrip tests were measured. Results Brain-derived neurotrophic factor levels increased significantly in both the functional training group (p<0.001) and Pilates group (p=0.005), with a more pronounced increase observed in the functional training group. The distance covered in the six-minute walk test also increased significantly in the functional training group (p=0.001) and was greater compared to both the Pilates (p<0.001) and control (p<0.001) groups. Conclusions Both multicomponent exercise programs led to increased BDNF levels after 12-week intervention. However, functional training yielded superior results compared to the Pilates method, possibly mediated by improvement in physical function.https://www.medwave.cl/investigacion/estudios/3010.htmlagingbrain-derived neurotrophic factorexercise |
| spellingShingle | Mayara Imaizumi Walter Sepulveda-Loyola Bruna Prado Gomes Camila Pereira Fabiana Cristina Scherer Regina Célia Poli-Frederico Andréa Name Colado Simão Vanessa Suziane Probst Denilson de Castro Teixeira Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women Medwave aging brain-derived neurotrophic factor exercise |
| title | Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women |
| title_full | Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women |
| title_fullStr | Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women |
| title_full_unstemmed | Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women |
| title_short | Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women |
| title_sort | effects of novel multicomponent exercise programs on brain derived neurotrophic factor levels and physical fitness in older women |
| topic | aging brain-derived neurotrophic factor exercise |
| url | https://www.medwave.cl/investigacion/estudios/3010.html |
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