Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome
Abstract Von Hippel-Lindau (VHL) syndrome is an autosomal dominant hereditary disease characterized with mutiple organ tumors. Tyrosine kinase inhibitor (TKI) is one of the targetd treatment for VHL syndrome. Lenvatinib (LEN), an oral small-molecule multiple TKI, and proteinuria is one of the most c...
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BMC
2025-07-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-04303-z |
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| author | Shuyu Zhang Yuehong Li Wen Wen |
| author_facet | Shuyu Zhang Yuehong Li Wen Wen |
| author_sort | Shuyu Zhang |
| collection | DOAJ |
| description | Abstract Von Hippel-Lindau (VHL) syndrome is an autosomal dominant hereditary disease characterized with mutiple organ tumors. Tyrosine kinase inhibitor (TKI) is one of the targetd treatment for VHL syndrome. Lenvatinib (LEN), an oral small-molecule multiple TKI, and proteinuria is one of the most common adverse events associated with LEN. We reported a case of lenvatinib-induced nephrotic syndrome in a Chinese patient with VHL syndrome. The renal biopsy was proved with thrombotic microangiopathy (TMA) and focal segmental glomerulosclerosis (FSGS)-like pattern. Drug-induced kidney injury deserves further attention. |
| format | Article |
| id | doaj-art-83ece6eb8f064cc48b5aaafec7669a49 |
| institution | DOAJ |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-83ece6eb8f064cc48b5aaafec7669a492025-08-20T03:04:30ZengBMCBMC Nephrology1471-23692025-07-012611610.1186/s12882-025-04303-zCase report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndromeShuyu Zhang0Yuehong Li1Wen Wen2Department of Nephrology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityDepartment of Nephrology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityDepartment of Nephrology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityAbstract Von Hippel-Lindau (VHL) syndrome is an autosomal dominant hereditary disease characterized with mutiple organ tumors. Tyrosine kinase inhibitor (TKI) is one of the targetd treatment for VHL syndrome. Lenvatinib (LEN), an oral small-molecule multiple TKI, and proteinuria is one of the most common adverse events associated with LEN. We reported a case of lenvatinib-induced nephrotic syndrome in a Chinese patient with VHL syndrome. The renal biopsy was proved with thrombotic microangiopathy (TMA) and focal segmental glomerulosclerosis (FSGS)-like pattern. Drug-induced kidney injury deserves further attention.https://doi.org/10.1186/s12882-025-04303-zDrug-induced kidney injuryNephrotic syndromeVon Hippel-Lindau syndromeTyrosine kinase inhibitorLenvatinib |
| spellingShingle | Shuyu Zhang Yuehong Li Wen Wen Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome BMC Nephrology Drug-induced kidney injury Nephrotic syndrome Von Hippel-Lindau syndrome Tyrosine kinase inhibitor Lenvatinib |
| title | Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome |
| title_full | Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome |
| title_fullStr | Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome |
| title_full_unstemmed | Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome |
| title_short | Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome |
| title_sort | case report nephrotic syndrome induced by lenvatinib treatment in a patient with von hippel lindau syndrome |
| topic | Drug-induced kidney injury Nephrotic syndrome Von Hippel-Lindau syndrome Tyrosine kinase inhibitor Lenvatinib |
| url | https://doi.org/10.1186/s12882-025-04303-z |
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