Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts
Photodynamic therapy (PDT) uses light energy to excite a photosensitizing agent, leading to production of reactive oxygen species, which exert cytotoxic effects on targeted cells. PDT has emerged as a promising therapeutic modality for the treatment of flat warts caused by human papillomavirus (HPV)...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006634 |
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| author | Weiming Zhang Zhao Jin Tingting Gao Li Fan Weizhen Wang Xianyu Zeng Li Qin |
| author_facet | Weiming Zhang Zhao Jin Tingting Gao Li Fan Weizhen Wang Xianyu Zeng Li Qin |
| author_sort | Weiming Zhang |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) uses light energy to excite a photosensitizing agent, leading to production of reactive oxygen species, which exert cytotoxic effects on targeted cells. PDT has emerged as a promising therapeutic modality for the treatment of flat warts caused by human papillomavirus (HPV) infection, by targeting infected keratinocytes and inactivating nonenveloped viral particles. Some patients with recalcitrant flat warts on the face who have poor response to traditional treatment often seek effective therapy to have the warts removed. In this report, we retrospectively evaluated the efficacy of topical 10% 5-aminolevulinic acid PDT (ALA-PDT) in the treatment of 15 patients with recalcitrant facial flat warts. Patients received treatment once every two weeks for a total of two or three sessions. At 24 weeks after the start of treatment, 86.67% of patients showed complete or excellent response. Further more, the remission rate of 100% lesion clearance was 46.67% (seven patients), and the remission rate of 70–100% lesion clearance was 40.00% (six patients). None of the patients experienced disease recurrence or progression. The adverse reactions were generally well tolerated by the patients and mostly resolved in a few days without special treatment. Our findings showed that topical 10% ALA-PDT is a safe and effective treatment for recalcitrant facial flat warts. |
| format | Article |
| id | doaj-art-83e650c231804bfcae6472711f1aac32 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-83e650c231804bfcae6472711f1aac322025-08-20T02:39:07ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510393410.1016/j.pdpdt.2023.103934Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat wartsWeiming Zhang0Zhao Jin1Tingting Gao2Li Fan3Weizhen Wang4Xianyu Zeng5Li Qin6Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Corresponding authors at: Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Corresponding authors at: Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.Photodynamic therapy (PDT) uses light energy to excite a photosensitizing agent, leading to production of reactive oxygen species, which exert cytotoxic effects on targeted cells. PDT has emerged as a promising therapeutic modality for the treatment of flat warts caused by human papillomavirus (HPV) infection, by targeting infected keratinocytes and inactivating nonenveloped viral particles. Some patients with recalcitrant flat warts on the face who have poor response to traditional treatment often seek effective therapy to have the warts removed. In this report, we retrospectively evaluated the efficacy of topical 10% 5-aminolevulinic acid PDT (ALA-PDT) in the treatment of 15 patients with recalcitrant facial flat warts. Patients received treatment once every two weeks for a total of two or three sessions. At 24 weeks after the start of treatment, 86.67% of patients showed complete or excellent response. Further more, the remission rate of 100% lesion clearance was 46.67% (seven patients), and the remission rate of 70–100% lesion clearance was 40.00% (six patients). None of the patients experienced disease recurrence or progression. The adverse reactions were generally well tolerated by the patients and mostly resolved in a few days without special treatment. Our findings showed that topical 10% ALA-PDT is a safe and effective treatment for recalcitrant facial flat warts.http://www.sciencedirect.com/science/article/pii/S1572100023006634Photodynamic therapyFacial flat warts5-Aminolevulinic acid |
| spellingShingle | Weiming Zhang Zhao Jin Tingting Gao Li Fan Weizhen Wang Xianyu Zeng Li Qin Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts Photodiagnosis and Photodynamic Therapy Photodynamic therapy Facial flat warts 5-Aminolevulinic acid |
| title | Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| title_full | Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| title_fullStr | Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| title_full_unstemmed | Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| title_short | Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| title_sort | topical 5 aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts |
| topic | Photodynamic therapy Facial flat warts 5-Aminolevulinic acid |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006634 |
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