Enhancement of respiratory virus infection by air pollutants
Viral respiratory infections are a leading cause of morbidity and mortality worldwide, posing significant economic and health burdens. This review examines how air pollutants promote viral respiratory infections and influence disease outcomes. Papers published within the last 15 years regarding inte...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008516 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390857365487616 |
|---|---|
| author | Ya-Fang Chiu Chih-Chen Kao Chi-Yuan Chen Chia-Ping Su Chia-Hao Ma Yamin Kyaw Jeng-How Yang |
| author_facet | Ya-Fang Chiu Chih-Chen Kao Chi-Yuan Chen Chia-Ping Su Chia-Hao Ma Yamin Kyaw Jeng-How Yang |
| author_sort | Ya-Fang Chiu |
| collection | DOAJ |
| description | Viral respiratory infections are a leading cause of morbidity and mortality worldwide, posing significant economic and health burdens. This review examines how air pollutants promote viral respiratory infections and influence disease outcomes. Papers published within the last 15 years regarding interactions between air pollutants and respiratory viruses were systematically identified and reviewed. The current evidence shows that common air pollutants can aggravate viral respiratory infections, either by assisting the spread, entry, and penetration of respiratory viruses to facilitate infection, or by interfering with host immune responses to heighten the risk of worse outcomes after infection. Moreover, air pollutants are known to increase the incidence of chronic obstructive pulmonary disease (COPD), diabetes, and asthma, which may weaken the effectiveness of the immune system against viral infections and increase the risks of excessive inflammation or cytokine storms. In addition, air pollutants can penetrate deep into the lower respiratory tract and various organs through the blood-air exchange system, leading to severe pulmonary and systemic adverse effects. In conclusion, air pollutants can affect a wide range of physiological aspects to exacerbate the impact of viral respiratory infections, and further research is critically needed to understand the underlying dynamics. |
| format | Article |
| id | doaj-art-83e0e619f21540918f7e64afe4c4a9d5 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-83e0e619f21540918f7e64afe4c4a9d52025-08-20T03:41:17ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211850610.1016/j.ecoenv.2025.118506Enhancement of respiratory virus infection by air pollutantsYa-Fang Chiu0Chih-Chen Kao1Chi-Yuan Chen2Chia-Ping Su3Chia-Hao Ma4Yamin Kyaw5Jeng-How Yang6Department of Microbiology and Immunology, Chang Gung University, Taoyuan City 333323, Taiwan; Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan City 333323, Taiwan; Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan City 333323, Taiwan; Division of Infectious Diseases, Department of Medicine, New Taipei Municipal Tucheng Hospital, New Taipei City 236017, Taiwan; Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan City 333423, Taiwan; Correspondence to: Department of Microbiology and Immunology, Chang Gung University, 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333323, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan City 333323, TaiwanDepartment of Microbiology and Immunology, Chang Gung University, Taoyuan City 333323, TaiwanDivision of Infectious Diseases, Department of Medicine, New Taipei Municipal Tucheng Hospital, New Taipei City 236017, Taiwan; School of Medicine, National Tsing Hua University, Hsinchu City 300044, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan City 333323, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan City 333323, TaiwanDivision of Infectious Diseases, Department of Medicine, New Taipei Municipal Tucheng Hospital, New Taipei City 236017, TaiwanViral respiratory infections are a leading cause of morbidity and mortality worldwide, posing significant economic and health burdens. This review examines how air pollutants promote viral respiratory infections and influence disease outcomes. Papers published within the last 15 years regarding interactions between air pollutants and respiratory viruses were systematically identified and reviewed. The current evidence shows that common air pollutants can aggravate viral respiratory infections, either by assisting the spread, entry, and penetration of respiratory viruses to facilitate infection, or by interfering with host immune responses to heighten the risk of worse outcomes after infection. Moreover, air pollutants are known to increase the incidence of chronic obstructive pulmonary disease (COPD), diabetes, and asthma, which may weaken the effectiveness of the immune system against viral infections and increase the risks of excessive inflammation or cytokine storms. In addition, air pollutants can penetrate deep into the lower respiratory tract and various organs through the blood-air exchange system, leading to severe pulmonary and systemic adverse effects. In conclusion, air pollutants can affect a wide range of physiological aspects to exacerbate the impact of viral respiratory infections, and further research is critically needed to understand the underlying dynamics.http://www.sciencedirect.com/science/article/pii/S0147651325008516Air pollutantsViral respiratory infectionsAsthmaChronic obstructive pulmonary diseaseObesityType 2 diabetes mellitus |
| spellingShingle | Ya-Fang Chiu Chih-Chen Kao Chi-Yuan Chen Chia-Ping Su Chia-Hao Ma Yamin Kyaw Jeng-How Yang Enhancement of respiratory virus infection by air pollutants Ecotoxicology and Environmental Safety Air pollutants Viral respiratory infections Asthma Chronic obstructive pulmonary disease Obesity Type 2 diabetes mellitus |
| title | Enhancement of respiratory virus infection by air pollutants |
| title_full | Enhancement of respiratory virus infection by air pollutants |
| title_fullStr | Enhancement of respiratory virus infection by air pollutants |
| title_full_unstemmed | Enhancement of respiratory virus infection by air pollutants |
| title_short | Enhancement of respiratory virus infection by air pollutants |
| title_sort | enhancement of respiratory virus infection by air pollutants |
| topic | Air pollutants Viral respiratory infections Asthma Chronic obstructive pulmonary disease Obesity Type 2 diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008516 |
| work_keys_str_mv | AT yafangchiu enhancementofrespiratoryvirusinfectionbyairpollutants AT chihchenkao enhancementofrespiratoryvirusinfectionbyairpollutants AT chiyuanchen enhancementofrespiratoryvirusinfectionbyairpollutants AT chiapingsu enhancementofrespiratoryvirusinfectionbyairpollutants AT chiahaoma enhancementofrespiratoryvirusinfectionbyairpollutants AT yaminkyaw enhancementofrespiratoryvirusinfectionbyairpollutants AT jenghowyang enhancementofrespiratoryvirusinfectionbyairpollutants |