Does inhaled salbutamol before surfactant therapy have any beneficial effect?
Beta (β)2 adrenergic receptors are present in alveolar type II cells. Previously, the beneficial effects of inhaled salbutamol treatment on respiratory outcomes were shown in premature infants with transient tachypnea of the newborn. We hypothesized that inhaled salbutamol would increase the effect...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2018-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/921 |
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| _version_ | 1850023967933333504 |
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| author | H Tolga Çelik Murat Yurdakök Ayşe Korkmaz Şule Yiğit |
| author_facet | H Tolga Çelik Murat Yurdakök Ayşe Korkmaz Şule Yiğit |
| author_sort | H Tolga Çelik |
| collection | DOAJ |
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Beta (β)2 adrenergic receptors are present in alveolar type II cells. Previously, the beneficial effects of inhaled salbutamol treatment on respiratory outcomes were shown in premature infants with transient tachypnea of the newborn. We hypothesized that inhaled salbutamol would increase the effects of surfactant on oxygenation in premature infants with respiratory distress syndrome (RDS). Inhaled salbutamol (0.15 mg/kg) or normal saline solution (0.30 ml/ kg) was administered as a single dose by micropump nebulizer 10 minutes before the first dose of surfactant (Poractant alfa) treatment in 40 infants with gestational ages ranging from 26 to 36 weeks. The effects of salbutamol therapy were evaluated by determining the duration of respiratory support, number of doses of surfactant, respiratory rate, heart rate, fraction of inspired oxygen, and partial pressure of arterial oxygen before and after salbutamol nebulization. No statistically significant difference was detected between the two groups in duration of respiratory support, number of doses of surfactant, respiratory rate, fraction of inspired oxygen, or partial pressure of arterial oxygen. In this study, no significant effect of inhaled salbutamol treatment on the surfactant therapy in premature infants with RDS was detected.
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| format | Article |
| id | doaj-art-83ddc4673a184b82a809e3de2e84aa2c |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-83ddc4673a184b82a809e3de2e84aa2c2025-08-20T03:01:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212018-12-0160610.24953/turkjped.2018.06.007Does inhaled salbutamol before surfactant therapy have any beneficial effect?H Tolga Çelik0Murat Yurdakök1Ayşe Korkmaz2Şule Yiğit3Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Beta (β)2 adrenergic receptors are present in alveolar type II cells. Previously, the beneficial effects of inhaled salbutamol treatment on respiratory outcomes were shown in premature infants with transient tachypnea of the newborn. We hypothesized that inhaled salbutamol would increase the effects of surfactant on oxygenation in premature infants with respiratory distress syndrome (RDS). Inhaled salbutamol (0.15 mg/kg) or normal saline solution (0.30 ml/ kg) was administered as a single dose by micropump nebulizer 10 minutes before the first dose of surfactant (Poractant alfa) treatment in 40 infants with gestational ages ranging from 26 to 36 weeks. The effects of salbutamol therapy were evaluated by determining the duration of respiratory support, number of doses of surfactant, respiratory rate, heart rate, fraction of inspired oxygen, and partial pressure of arterial oxygen before and after salbutamol nebulization. No statistically significant difference was detected between the two groups in duration of respiratory support, number of doses of surfactant, respiratory rate, fraction of inspired oxygen, or partial pressure of arterial oxygen. In this study, no significant effect of inhaled salbutamol treatment on the surfactant therapy in premature infants with RDS was detected. https://turkjpediatr.org/article/view/921RDSinfantinhaled salbutamolneonatenewbornpremature |
| spellingShingle | H Tolga Çelik Murat Yurdakök Ayşe Korkmaz Şule Yiğit Does inhaled salbutamol before surfactant therapy have any beneficial effect? The Turkish Journal of Pediatrics RDS infant inhaled salbutamol neonate newborn premature |
| title | Does inhaled salbutamol before surfactant therapy have any beneficial effect? |
| title_full | Does inhaled salbutamol before surfactant therapy have any beneficial effect? |
| title_fullStr | Does inhaled salbutamol before surfactant therapy have any beneficial effect? |
| title_full_unstemmed | Does inhaled salbutamol before surfactant therapy have any beneficial effect? |
| title_short | Does inhaled salbutamol before surfactant therapy have any beneficial effect? |
| title_sort | does inhaled salbutamol before surfactant therapy have any beneficial effect |
| topic | RDS infant inhaled salbutamol neonate newborn premature |
| url | https://turkjpediatr.org/article/view/921 |
| work_keys_str_mv | AT htolgacelik doesinhaledsalbutamolbeforesurfactanttherapyhaveanybeneficialeffect AT muratyurdakok doesinhaledsalbutamolbeforesurfactanttherapyhaveanybeneficialeffect AT aysekorkmaz doesinhaledsalbutamolbeforesurfactanttherapyhaveanybeneficialeffect AT suleyigit doesinhaledsalbutamolbeforesurfactanttherapyhaveanybeneficialeffect |