Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism
Purpose. Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and i...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4713906 |
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| author | Zhoujun Liu Yu Chen Guofang Chen Xiaodong Mao Xiao Wei Xingjia Li Yijiao Xu Fan Jiang Kun Wang Chao Liu |
| author_facet | Zhoujun Liu Yu Chen Guofang Chen Xiaodong Mao Xiao Wei Xingjia Li Yijiao Xu Fan Jiang Kun Wang Chao Liu |
| author_sort | Zhoujun Liu |
| collection | DOAJ |
| description | Purpose. Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in young male offspring and the possible underlying mechanisms. Methods. Female rats were divided into a maternal hypothyroidism (MH) group, which received water containing 0.02% 6-propyl-2-thiouracil before and during pregnancy to induce hypothyroidism, and a control group which consumed tap water. Results. Our results showed that there were no differences of islets structure between the offspring from the two groups, but glucose metabolism was impaired with higher plasma glucose concentrations at 0 and 15 min in the OGTT in 8-week-old offspring of the MH group. From birth to 8 weeks, pancreatic TRβ1 and TRβ2 mRNA level declined significantly in MH offspring, accompanied by decreased Ki67 and insulin mRNA expression. Conclusions. Maternal hypothyroidism results in impaired pancreatic insulin synthesis and pancreatic cell proliferation in neonatal offspring and subsequent glucose intolerance in young offspring, which may be related to TRβ gene downregulation in the pancreas. |
| format | Article |
| id | doaj-art-83d79ab2a7fc4bb5ac99aa587481ae15 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-83d79ab2a7fc4bb5ac99aa587481ae152025-02-03T05:47:44ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/47139064713906Impaired Glucose Metabolism in Young Offspring of Female Rats with HypothyroidismZhoujun Liu0Yu Chen1Guofang Chen2Xiaodong Mao3Xiao Wei4Xingjia Li5Yijiao Xu6Fan Jiang7Kun Wang8Chao Liu9The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaEndocrine Research Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaEndocrine Research Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaEndocrine Research Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaEndocrine Research Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaEndocrine Research Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaThe Third College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaThe Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaPurpose. Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in young male offspring and the possible underlying mechanisms. Methods. Female rats were divided into a maternal hypothyroidism (MH) group, which received water containing 0.02% 6-propyl-2-thiouracil before and during pregnancy to induce hypothyroidism, and a control group which consumed tap water. Results. Our results showed that there were no differences of islets structure between the offspring from the two groups, but glucose metabolism was impaired with higher plasma glucose concentrations at 0 and 15 min in the OGTT in 8-week-old offspring of the MH group. From birth to 8 weeks, pancreatic TRβ1 and TRβ2 mRNA level declined significantly in MH offspring, accompanied by decreased Ki67 and insulin mRNA expression. Conclusions. Maternal hypothyroidism results in impaired pancreatic insulin synthesis and pancreatic cell proliferation in neonatal offspring and subsequent glucose intolerance in young offspring, which may be related to TRβ gene downregulation in the pancreas.http://dx.doi.org/10.1155/2019/4713906 |
| spellingShingle | Zhoujun Liu Yu Chen Guofang Chen Xiaodong Mao Xiao Wei Xingjia Li Yijiao Xu Fan Jiang Kun Wang Chao Liu Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism Journal of Diabetes Research |
| title | Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism |
| title_full | Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism |
| title_fullStr | Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism |
| title_full_unstemmed | Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism |
| title_short | Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism |
| title_sort | impaired glucose metabolism in young offspring of female rats with hypothyroidism |
| url | http://dx.doi.org/10.1155/2019/4713906 |
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