Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study
Abstract Background This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D). Methods This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-ad...
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2024-12-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-024-00884-y |
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| author | Takahiro Ichikawa Yoshitaka Hashimoto Yusuke Igarashi Sayaka Kawai Ayumi Kaji Ryosuke Sakai Takafumi Osaka Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Masahide Hamaguchi Michiaki Fukui |
| author_facet | Takahiro Ichikawa Yoshitaka Hashimoto Yusuke Igarashi Sayaka Kawai Ayumi Kaji Ryosuke Sakai Takafumi Osaka Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Masahide Hamaguchi Michiaki Fukui |
| author_sort | Takahiro Ichikawa |
| collection | DOAJ |
| description | Abstract Background This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D). Methods This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal). Gut microbial composition was evaluated via 16S rRNA gene sequencing. We investigated the association between gut microbiota, previously identified as relevant to T2D, and the density of UPFs intake using Spearman rank correlation coefficients. Multiple regression analysis, adjusting for age, sex, BMI, smoking status, exercise, and medication use, was conducted to further investigate these associations. Results The mean age of participants was 68 (63–74) years. The density of UPFs intake showed significant associations with Bifidobacterium (r = 0.11, p = 0.031), Lactobacillus (r = 0.11, p = 0.046), Ruminococcus (r = −0.12, p = 0.019), Roseburia (r = 0.11, p = 0.045). After adjusting for covariates in multiple regression analysis, Ruminococcus and Roseburia showed modest negative (β = −0.11, p = 0.038) and positive (β = 0.12, p = 0.033) correlations, with the density of UPFs intake among participants with T2D, respectively. Conclusions The density of UPFs intake was modestly inversely associated with Ruminococcus among patients with T2D and modestly positively associated with Roseburia. |
| format | Article |
| id | doaj-art-83d59a1dd5d846c0a9cc5f12f85e0e8a |
| institution | DOAJ |
| issn | 1743-7075 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-83d59a1dd5d846c0a9cc5f12f85e0e8a2025-08-20T02:39:51ZengBMCNutrition & Metabolism1743-70752024-12-012111910.1186/s12986-024-00884-yAssociation between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional studyTakahiro Ichikawa0Yoshitaka Hashimoto1Yusuke Igarashi2Sayaka Kawai3Ayumi Kaji4Ryosuke Sakai5Takafumi Osaka6Ryo Inoue7Saori Kashiwagi8Katsura Mizushima9Kazuhiko Uchiyama10Tomohisa Takagi11Yuji Naito12Masahide Hamaguchi13Michiaki Fukui14Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineLaboratory of Animal Science, Kyoto Prefectural UniversityMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineMolecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineAbstract Background This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D). Methods This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal). Gut microbial composition was evaluated via 16S rRNA gene sequencing. We investigated the association between gut microbiota, previously identified as relevant to T2D, and the density of UPFs intake using Spearman rank correlation coefficients. Multiple regression analysis, adjusting for age, sex, BMI, smoking status, exercise, and medication use, was conducted to further investigate these associations. Results The mean age of participants was 68 (63–74) years. The density of UPFs intake showed significant associations with Bifidobacterium (r = 0.11, p = 0.031), Lactobacillus (r = 0.11, p = 0.046), Ruminococcus (r = −0.12, p = 0.019), Roseburia (r = 0.11, p = 0.045). After adjusting for covariates in multiple regression analysis, Ruminococcus and Roseburia showed modest negative (β = −0.11, p = 0.038) and positive (β = 0.12, p = 0.033) correlations, with the density of UPFs intake among participants with T2D, respectively. Conclusions The density of UPFs intake was modestly inversely associated with Ruminococcus among patients with T2D and modestly positively associated with Roseburia.https://doi.org/10.1186/s12986-024-00884-yUltra-processed food consumptionGut microbiotaType 2 diabetes |
| spellingShingle | Takahiro Ichikawa Yoshitaka Hashimoto Yusuke Igarashi Sayaka Kawai Ayumi Kaji Ryosuke Sakai Takafumi Osaka Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Masahide Hamaguchi Michiaki Fukui Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study Nutrition & Metabolism Ultra-processed food consumption Gut microbiota Type 2 diabetes |
| title | Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study |
| title_full | Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study |
| title_fullStr | Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study |
| title_full_unstemmed | Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study |
| title_short | Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study |
| title_sort | association between gut microbiota and ultra processed foods consumption among the patients with type 2 diabetes a cross sectional study |
| topic | Ultra-processed food consumption Gut microbiota Type 2 diabetes |
| url | https://doi.org/10.1186/s12986-024-00884-y |
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