Using major histocompatibility complex (MHC) II expression to predict antitumor response to CD4 + lymphocyte depletion

Using major histocompatibility complex (MHC) II expression to predict antitumor response to CD4 + lymphocyte depletion

Abstract Immunotherapy targeting CD4 + FoxP3 + regulatory T cells (Tregs) through CD4 + lymphocyte depletion is being investigated as cancer treatment. This study examines the efficacy and limitations of CD4 depletion across various cancer models. We examined CD4 depletion in syngeneic mouse tumor m...

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Bibliographic Details
Main Authors: Yanping Wang, Minhyung Kim, Shengchen Su, Lahiruni Halwatura, Sungyong You, Hyung L. Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
CD4 depletion
MHC II
Tumor immunology
Online Access:https://doi.org/10.1038/s41598-025-88972-8
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