Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis
Background: Ocular surface disorders (OSD) are prevalent, affecting millions globally. Existing treatments often have limitations, especially for severe cases. Objective: To evaluate the safety and efficacy of topical insulin for anaging OSDs. Methods: A comprehensive search of major databases (PubM...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Permanyer
2025-04-01
|
| Series: | Revista Mexicana de Endocrinología, Metabolismo y Nutrición |
| Subjects: | |
| Online Access: | http://www.revistadeendocrinologia.com/frame_eng.php?id=367 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850117910209495040 |
|---|---|
| author | Luís J. de Oliveira-Andrade Gabriela C. Matos-de Oliveira Alcina Ma. Vinhaes-Bittencourt Tulio Matos-David Roseanne Montargil-Rocha Luís Matos-De Oliveira |
| author_facet | Luís J. de Oliveira-Andrade Gabriela C. Matos-de Oliveira Alcina Ma. Vinhaes-Bittencourt Tulio Matos-David Roseanne Montargil-Rocha Luís Matos-De Oliveira |
| author_sort | Luís J. de Oliveira-Andrade |
| collection | DOAJ |
| description | Background: Ocular surface disorders (OSD) are prevalent, affecting millions globally. Existing treatments often have limitations, especially for severe cases. Objective: To evaluate the safety and efficacy of topical insulin for anaging OSDs. Methods: A comprehensive search of major databases (PubMed, Scopus, Embase, and Cochrane Library) identified studies investigating topical insulin for eye conditions. Rigorous screening and quality assessment were conducted. Data on safety, efficacy, and outcomes were extracted and analyzed. Results: Ten studies (1 case-control, 3 randomized prospective, 3 retrospective, and 3 double-blind) were included, exploring conditions like corneal ulcers, persistent defects, and dry eye disease. Findings suggest that topical insulin may be safe and effective for various OSD. A meta-analysis demonstrated significantly faster healing times with topical insulin compared to placebo. Conclusion: This review provides promising evidence for the therapeutic potential of topical insulin for diverse OSD. Despite limitations, topical insulin may be a viable treatment for OSD.
|
| format | Article |
| id | doaj-art-83cf1f4d89624fb89a005f62d3636ea1 |
| institution | OA Journals |
| issn | 2462-4144 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Mexicana de Endocrinología, Metabolismo y Nutrición |
| spelling | doaj-art-83cf1f4d89624fb89a005f62d3636ea12025-08-20T02:35:59ZengPermanyerRevista Mexicana de Endocrinología, Metabolismo y Nutrición2462-41442025-04-0112210.24875/RME.24000021Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysisLuís J. de Oliveira-Andrade0Gabriela C. Matos-de Oliveira1Alcina Ma. Vinhaes-Bittencourt2Tulio Matos-David3Roseanne Montargil-Rocha4Luís Matos-De Oliveira5Department of Health, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, BrasilSchool of Medicine, Uni-FTC, Salvador, Bahia, BrasilSchool of Medicine, Universidade Federal da Bahia, Salvador, Bahia, BrasilSchool of Medicine, Universidade Federal da Bahia, Salvador, Bahia, BrasilDepartment of Health, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, BrasilSchool of Medicine and Public Health, Salvador, Bahia, BrasilBackground: Ocular surface disorders (OSD) are prevalent, affecting millions globally. Existing treatments often have limitations, especially for severe cases. Objective: To evaluate the safety and efficacy of topical insulin for anaging OSDs. Methods: A comprehensive search of major databases (PubMed, Scopus, Embase, and Cochrane Library) identified studies investigating topical insulin for eye conditions. Rigorous screening and quality assessment were conducted. Data on safety, efficacy, and outcomes were extracted and analyzed. Results: Ten studies (1 case-control, 3 randomized prospective, 3 retrospective, and 3 double-blind) were included, exploring conditions like corneal ulcers, persistent defects, and dry eye disease. Findings suggest that topical insulin may be safe and effective for various OSD. A meta-analysis demonstrated significantly faster healing times with topical insulin compared to placebo. Conclusion: This review provides promising evidence for the therapeutic potential of topical insulin for diverse OSD. Despite limitations, topical insulin may be a viable treatment for OSD. http://www.revistadeendocrinologia.com/frame_eng.php?id=367Topical insulin. Ocular conditions. Systematic review. Meta-analysis. |
| spellingShingle | Luís J. de Oliveira-Andrade Gabriela C. Matos-de Oliveira Alcina Ma. Vinhaes-Bittencourt Tulio Matos-David Roseanne Montargil-Rocha Luís Matos-De Oliveira Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis Revista Mexicana de Endocrinología, Metabolismo y Nutrición Topical insulin. Ocular conditions. Systematic review. Meta-analysis. |
| title | Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis |
| title_full | Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis |
| title_fullStr | Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis |
| title_full_unstemmed | Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis |
| title_short | Safety and efficacy of topical insulin in ocular surface disorders: a systematic review and meta-analysis |
| title_sort | safety and efficacy of topical insulin in ocular surface disorders a systematic review and meta analysis |
| topic | Topical insulin. Ocular conditions. Systematic review. Meta-analysis. |
| url | http://www.revistadeendocrinologia.com/frame_eng.php?id=367 |
| work_keys_str_mv | AT luisjdeoliveiraandrade safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis AT gabrielacmatosdeoliveira safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis AT alcinamavinhaesbittencourt safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis AT tuliomatosdavid safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis AT roseannemontargilrocha safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis AT luismatosdeoliveira safetyandefficacyoftopicalinsulininocularsurfacedisordersasystematicreviewandmetaanalysis |