NQO1 antagonizes PM2.5-induced apoptosis of Sertoli cells by activating the UPRmt pathway
The mechanism by which NQO1 antagonizes PM2.5-induced apoptosis in Sertoli cells through activation of the mitochondrial unfolded protein response (UPRmt) was investigated. A reproductive toxicity model was established using TM4 cells exposed to PM2.5 (50 μg/mL, 24 h). Transcriptome sequencing and b...
Saved in:
| Main Authors: | Cao Wang, Qing Xiao, Mingchen Xiao, Yu Chu, Yaya Ai, Zhen Luo, Guangxu Zhou, Kaiyi Mao, Bin Liu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325010747 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chlorogenic acid inhibits Pseudomonas toxin pyocyanin and activates mitochondrial UPR to protect host against pathogen infection
by: Yi Xiao, et al.
Published: (2025-02-01) -
Reduced Expression of UPRmt Proteins HSP10, HSP60, HTRA2, OMA1, SPG7, and YME1L Is Associated with Accelerated Heart Failure in Humans
by: Petra Bakovic, et al.
Published: (2025-05-01) -
GrpEL1 overexpression mitigates hippocampal neuron damage via mitochondrial unfolded protein response after experimental status epilepticus
by: Minjia Xie, et al.
Published: (2025-03-01) -
miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis
by: Yixuan Wang, et al.
Published: (2025-02-01) -
Curcumin mimics of potential chemoprevention with NQO1 induction properties
by: Dalia R. Aboshouk, et al.
Published: (2025-01-01)