The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages
Macrophages are multifunctional immune cells whose functions depend on polarizable phenotypes and the microenvironment. Macrophages have two phenotypes, including the M1 proinflammatory phenotype and the M2 anti-inflammatory phenotype, which play important roles in many inflammatory responses and di...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5577577 |
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| _version_ | 1849402182288277504 |
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| author | Shaojuan Liu Jie Yang Zhenfang Wu |
| author_facet | Shaojuan Liu Jie Yang Zhenfang Wu |
| author_sort | Shaojuan Liu |
| collection | DOAJ |
| description | Macrophages are multifunctional immune cells whose functions depend on polarizable phenotypes and the microenvironment. Macrophages have two phenotypes, including the M1 proinflammatory phenotype and the M2 anti-inflammatory phenotype, which play important roles in many inflammatory responses and diseases. α-Ketoglutarate is a key metabolite of the TCA cycle and can regulate the phenotype of macrophage polarization to exert anti-inflammatory effects in many inflammation-related diseases. In this review, we primarily elucidate the metabolism, regulatory mechanism, and perspectives of α-ketoglutarate on macrophages. The regulation of macrophage polarization by α-ketoglutarate may provide a promising target for the prevention and therapy of inflammatory diseases and is beneficial to animal health. |
| format | Article |
| id | doaj-art-83c9215fd022498cbecc3ee33ecd0774 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-83c9215fd022498cbecc3ee33ecd07742025-08-20T03:37:37ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/55775775577577The Regulatory Role of α-Ketoglutarate Metabolism in MacrophagesShaojuan Liu0Jie Yang1Zhenfang Wu2College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong 510642, ChinaMacrophages are multifunctional immune cells whose functions depend on polarizable phenotypes and the microenvironment. Macrophages have two phenotypes, including the M1 proinflammatory phenotype and the M2 anti-inflammatory phenotype, which play important roles in many inflammatory responses and diseases. α-Ketoglutarate is a key metabolite of the TCA cycle and can regulate the phenotype of macrophage polarization to exert anti-inflammatory effects in many inflammation-related diseases. In this review, we primarily elucidate the metabolism, regulatory mechanism, and perspectives of α-ketoglutarate on macrophages. The regulation of macrophage polarization by α-ketoglutarate may provide a promising target for the prevention and therapy of inflammatory diseases and is beneficial to animal health.http://dx.doi.org/10.1155/2021/5577577 |
| spellingShingle | Shaojuan Liu Jie Yang Zhenfang Wu The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages Mediators of Inflammation |
| title | The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages |
| title_full | The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages |
| title_fullStr | The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages |
| title_full_unstemmed | The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages |
| title_short | The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages |
| title_sort | regulatory role of α ketoglutarate metabolism in macrophages |
| url | http://dx.doi.org/10.1155/2021/5577577 |
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