Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case
Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accesso...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/5160180 |
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| author | Gabriel M. Groisman |
| author_facet | Gabriel M. Groisman |
| author_sort | Gabriel M. Groisman |
| collection | DOAJ |
| description | Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections. |
| format | Article |
| id | doaj-art-83bf73d4a6884b3b835fb51727d7094c |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-83bf73d4a6884b3b835fb51727d7094c2025-08-20T02:09:07ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/51601805160180Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a CaseGabriel M. Groisman0The Institute of Pathology, Hillel Yaffe Medical Center, Hadera, IsraelDespite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.http://dx.doi.org/10.1155/2016/5160180 |
| spellingShingle | Gabriel M. Groisman Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case Case Reports in Pathology |
| title | Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case |
| title_full | Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case |
| title_fullStr | Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case |
| title_full_unstemmed | Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case |
| title_short | Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case |
| title_sort | lobular carcinoma of the breast metastatic to the spleen and accessory spleen report of a case |
| url | http://dx.doi.org/10.1155/2016/5160180 |
| work_keys_str_mv | AT gabrielmgroisman lobularcarcinomaofthebreastmetastatictothespleenandaccessoryspleenreportofacase |